In this article, an S-band two-way inverted asymmetrical Doherty power amplifier (IADPA) using LDMOS FET is proposed. Due to the compact inverted load network with low inserted loss and the asymmetrical structure, the amplifier exhibits a high efficiency when operating at an output power back-off beyond 6 dB. For experimental verification, an IADPA has been implemented and a modulated Long Term Evolution (LTE) signal with 20-MHz channel bandwidth is applied as excitation. According to the measured results, the proposed amplifier can achieve a drain efficiency of 47.6% at the output power back-off of 7.7 dB from saturated power point and an adjacent channel power ratio (ACPR) less than −53 dBc with digital pre-distortion (DPD) when operating at 2.65 GHz.