A broadband Tm/Ho-doped fiber laser tunable from 1.8 to 2.09 µm for intracavity absorption spectroscopy

Fjodorow, Peter; Hellmig, Ortwin; Baev, V. M.

doi:10.1007/s00340-018-6932-y

Cited by 18 publications

(2 citation statements)

References 25 publications

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“…Few spectroscopic techniques are able to fulfill these demands and a new promising candidate is the intracavity absorption spectroscopy (ICAS). Using a broadband tunable Tm/Ho-doped fiber laser (4780-5560 cm −1 ) and placing the sample inside the cavity, simultaneous detection of H 2 [119]. Furthermore, also broadband absorbing molecules, such as acetone [152], can be detected in breath samples with a portable and compact system.…”

Section: Opportunitiesmentioning

confidence: 99%

Laser spectroscopy for breath analysis: towards clinical implementation

et al. 2018

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Detection and analysis of volatile compounds in exhaled breath represents an attractive tool for monitoring the metabolic status of a patient and disease diagnosis, since it is non-invasive and fast. Numerous studies have already demonstrated the benefit of breath analysis in clinical settings/applications and encouraged multidisciplinary research to reveal new insights regarding the origins, pathways, and pathophysiological roles of breath components. Many breath analysis methods are currently available to help explore these directions, ranging from mass spectrometry to laser-based spectroscopy and sensor arrays. This review presents an update of the current status of optical methods, using near and mid-infrared sources, for clinical breath gas analysis over the last decade and describes recent technological developments and their applications. The review includes: tunable diode laser absorption spectroscopy, cavity ring-down spectroscopy, integrated cavity output spectroscopy, cavity-enhanced absorption spectroscopy, photoacoustic spectroscopy, quartz-enhanced photoacoustic spectroscopy, and optical frequency comb spectroscopy. A SWOT analysis (strengths, weaknesses, opportunities, and threats) is presented that describes the laser-based techniques within the clinical framework of breath research and their appealing features for clinical use.

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Section: Opportunitiesmentioning

confidence: 99%

Laser spectroscopy for breath analysis: towards clinical implementation

et al. 2018

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“…15,23 In intracavity absorption spectroscopy (ICAS), the sample is placed within the resonator of a fiber laser. 24 Typical absorption sensitivities achieved with CEAS are sufficient for the detection of almost all small biomarker molecules in exhaled breath, including those present at low ppb or ppt concentrations, such as NO, hydrogen cyanide (HCN), hydrogen sulfide (H 2 S), carbonyl sulfide (OCS), and formaldehyde (CH 2 O).…”

Section: Cavity-enhanced Laser Absorption Spectroscopymentioning

confidence: 99%