During the third millennium cal BC, the Indus communities exploited great quantities of chert from the Rohri Hills mines in Upper Sindh for making different types of artifacts. This paper discusses the way chert was transported to the Indus Civilization centers and the problems related to the type, quantity, and quality of raw material and artifacts that were transported, including when, why, and where. This paper raises the question of land and water transport. Both these methods were probably used according to the landscape location of the Indus sites. Another problem concerns the landscape characteristics of the Indus Valley during the Bronze Age before the climate changes that took place around the end of the third millennium cal BC and the disappearance of the Hakra River, which was an important watercourse during the Indus phase. What do we know of the way the Indus communities exploited, transported, and circulated knappable chert? Why have the Indus settlements excavated around the Rohri Hills, the largest chert mines of the Indian Subcontinent, yielded little evidence of chert artifacts and nodules? What do we know of this important problem, which is strictly related to the everyday life of the Indus communities and their economy? Why this problem has been systematically neglected by most archaeologists despite its importance?