A brownish-red plaque in an adult

Harman, Mehmet; Akdeniz, Sedat; Balci, Gokcen; Uzunlar, Ali Kemal

doi:10.4103/0378-6323.45244

Cited by 5 publications

(12 citation statements)

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“…Systemic symptoms may include urtication, pruritus, blistering, flushing, dyspnea, hypotension or gastrointestinal complaints, because of the release of histamine and other mediators. Ours is the 18th case of adult‐onset mastocytoma reported in the literature in English . Since systemic involvement associated with these lesions has not been described to date, we anticipate a good prognosis.…”

Section: Introductionmentioning

confidence: 71%

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Pleomorphic mastocytoma in an adult

et al. 2017

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Cutaneous mastocytoma (CM) is a localized variant of mastocytosis, characterized by an over-accumulation of mast cells in the skin, without extra-cutaneous organ involvement. It is defined as the presence of up to 3 isolated mast-cell skin lesions and commonly develops in newborns and children. We report the case of a 35-year-old healthy Caucasian woman presenting with a 4-year history of a pruritic brown plaque on her left breast. Hematoxylin-eosin staining showed a dense dermal infiltrate of atypical mast cells extending to the subcutis. The cells presented a marked nuclear pleomorphism with bilobed and multilobed nuclei. Immunohistochemical studies revealed strongly expressed KIT (CD117) and CD25 proteins. Serum tryptase levels and bone marrow biopsy were normal. The diagnosis was a solitary cutaneous pleomorphic mastocytoma. This case can be added to 17 other cases of adult mastocytoma documented in the literature, although, unlike other reported cases, and as far as we are aware, this is the first case of pleomorphic mastocytoma in an adult.

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Section: Introductionmentioning

confidence: 71%

“…CM, a localized variant of mastocytosis, is characterized by an over‐accumulation of mast cells in the skin without extracutaneous organ involvement . Adult onset of CM is rare, with only 17 other cases reported in the literature in English …”

Section: Discussionmentioning

confidence: 99%

Pleomorphic mastocytoma in an adult

et al. 2017

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“…The hyperpigmentation associated with mastocytomas has been postulated to be secondary to induction of melanocytes by increased local concentrations of soluble mast cell growth factors from the mast cell lesions of cutaneous mastocytosis [13,19–21]. In addition to a melanocytic nevus (or a dysplastic nevus [current report] or Spitz nevus [11], the clinical differential diagnosis of solitary mastocytoma includes chronic arthropod bite reaction [15], cyst [8], granuloma [8], hidrocystoma [15], leukemia cutis [11], and xanthogranuloma [11].…”

Section: Discussionmentioning

confidence: 99%

Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment

Cohen

2016

Dermatol Pract Concept

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Background:Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare.Purpose:A woman with the new onset of solitary mastocytoma is described. The clinical features of patients with adult-onset solitary mastocytoma are summarized. Recommendations for the evaluation and treatment of individuals with adult-onset solitary mastocytoma are proposed.Methods:PubMed was searched with the key words: adult, CD2, CD25, cell, cutaneous, disease, KIT, KIT D816V, mast, mastocytoma, mutation, pigmentosa, solitary, tryptase, and urticarial. The papers generated by the search, and their references, were reviewed.Results:A 38-year-old Taiwanese woman presented with an asymptomatic brown patch, which morphologically mimicked a dysplastic nevus, on her right abdomen; biopsy demonstrated a solitary mastocytoma. Comprehensive evaluation (including serologic and bone marrow examination) excluded systemic mastocytosis and her residual mastocytoma is being monitored. Adult-onset solitary mastocytoma has been described in 16 patients. Lesions were either on the head and neck (5/14), torso (5/14) or extremities (4/14). Urtication following lesion rubbing was noted in 79% (11/14) of patients. Excision of the mastocytoma [75% (9/12)] was the most common treatment. Other management approaches included corticosteroids (topical or intralesional), antihistamines (systemic) or observation. Systemic symptoms were noted in 5 patients: flushing (3 women) and pruritus (3 women); gastrointestinal symptoms and headaches, flushing and/or anaphylaxis were each noted in one woman. None of the patients with adult-onset solitary mastocytoma had systemic mastocytosis; however, only 3 women were evaluated for systemic mastocytosis.Conclusions:Systemic mastocytosis is common in adults with new onset cutaneous mastocytosis. Therefore, a conservative work up for new onset solitary mastocytosis in adults is proposed to include complete blood cell counts, serum chemistries (including liver function tests), and serum tryptase level and bone marrow biopsy to evaluate for mast cell clusters, morphology and immunophenotype and KIT gene mutation in codon 816. Similar serologic testing should be considered annually for adult-onset solitary mastocytosis patients without systemic disease.

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“…Our recent publications regarding the value of cytology in erosive–vesiculobullous, granulomatous, and tumoral diseases have prompted a worldwide interest in dermatological cytology . Some dermatology clinics, which previously used cytology for a few diseases only, have now begun to use this method for more diseases and to report the relevant findings . Experience is an essential component of cytological analysis in all skin conditions .…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11][12] Some dermatology clinics, which previously used cytology for a few diseases only, have now begun to use this method for more diseases and to report the relevant findings. 13 Experience is an essential component of cytological analysis in all skin conditions. 12,14,15 For this reason, telecytological consultation has recently been utilized in some cases that cannot be diagnosed by cytological evaluation.…”

Section: Introductionmentioning

confidence: 99%