A Bullous Variant of Kaposi's Sarcoma in an Elderly Female

Recht, Bernard; Nickoloff, Brian J.; Wood, Gary S.

doi:10.1111/j.1524-4725.1986.tb02104.x

Cited by 11 publications

(7 citation statements)

References 16 publications

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“…4 These vascular channels are dilated and bizarrely shaped and are located in the upper portion of the dermis. 5,6 Clinically, lymphangioma-like KS can present as a typical-appearing KS but also has a unique clinical appearance termed bullalike. However, a bulla-like clinical appearance may be indicative of this histological pattern.…”

Section: Lymphangioma-like Kaposi's Sarcoma: Report Of Four Cases Andmentioning

confidence: 99%

Inflammatory nuchal-occipital port-wine stains

Tay

Morelli

Weston

1996

Journal of the American Academy of Dermatology

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Section: Lymphangioma-like Kaposi's Sarcoma: Report Of Four Cases Andmentioning

confidence: 99%

Inflammatory nuchal-occipital port-wine stains

Tay

Morelli

Weston

1996

Journal of the American Academy of Dermatology

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“…The histological findings of the lymphangioma‐like variant have been described as the presence of vascular channels lined by banal‐appearing endothelia permeating the dermis in the absence of a spindle cell proliferation 4 . These vascular channels are dilated and bizarrely shaped and are located in the upper portion of the dermis 5,6 . Clinically, lymphangioma‐like KS can present as a typical‐appearing KS but also has a unique clinical appearance termed bulla‐like.…”

mentioning

confidence: 99%

Lymphangioma‐like Kaposi's sarcoma: report of four cases and review

Sánchez

Ferrufino

Bravo

et al. 2006

Acad Dermatol Venereol

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EditorKaposi's sarcoma (KS) is characterized by a wide range of cutaneous manifestations, such as macules, plaques, papules and nodules. However, some variants are only rarely observed and reported. 'Lymphangioma-like' or 'bullous KS' is very uncommon. The clinical features were first reported in 1957 by Ronchese and Kern. 1 Since then, only 21 cases have been published. We report the clinical correlation of four rare cases of lymphangioma-like KS with bulla-like lesions and review the literature.The first patient was a 65-year-old man with an 8-year history of pain and pruritus on the upper and lower extremities who presented with bulla-like lesions on both arms. These lesions varied in size from 0.5 to 2 cm in diameter. The second patient was an 89-year-old indigenous woman with a 1-month history of pain and oedema who presented with multiple nearly confluent violaceous nodules on her legs. Nodules varied in size from 0.5 to 1 cm in diameter. She also presented two bulla-like lesions on her left ankle. The third patient was a 61-year-old man with a 1-year history of pain and oedema who presented with multiple confluent brownish nodules and plaques on the lower extremities. Nodules varied in size from 0.5 to 1.5 cm in diameter. In these three patients, no lymphadenomegaly was clinically detectable, results of blood tests were within normal limits, and HIV serology proved negative. The fourth patient was a 36-year-old woman with a 5-year history of AIDS who presented with multiple violaceous plaques and nodules on her legs, and macules on her soft palate. Seven months before this she had been diagnosed with KS on the basis of her clinical presentation and histopathological features. At that time her lower extremities were treated with external radiation. Two months later, she experienced a rapid onset of bulla-like lesions on her right leg ( fig. 1). She was treated with systemic chemotherapy with no apparent response. The lesions had a tense consistency and were easily friable. Her CD4 count was less than 10 cells/mL and the viral load was 100 000 copies/mL. The patient died about 2 weeks later. fig. 1 Multiple confluent nodules and bulla-like lesions on the right foot.

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“…Factors inducing the development of bullous lesions in KS include the corruption of lymphatic drainage by tumor tissue, lymphaticovenous shunts formed on neoplastic vascular canals, lymphovascular invasion of tumor cells, the involvement of regional lymph nodes, and/or cytokine release. All of these factors can cause the development of stasis in cutaneous lymphatic vessels, dermal edema, and hence the formation of intraepidermal/subepidermal bulla secondary to absorption of lymphatic liquid by the epidermis [1,14-17,22]. …”

Section: Discussionmentioning

confidence: 99%

Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma

et al. 2012

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BackgroundIn this study, the clinical and morphological features of vesiculobullous lesions observed in Kaposi sarcoma are analyzed, and the features of bullous Kaposi sarcoma cases are emphasized.MethodsA total of 178 biopsy materials of 75 cases diagnosed as classic-type cutaneous Kaposi sarcoma were reviewed. Twenty-five cases showing vesiculobullous features were included in the study. Tumor, epidermis, dermis, and clinical data regarding these cases was evaluated.ResultsVesicular changes were observed in 21 (12%) out of 178 lesions of the 75 cases, while bullous changes were present in only 4 (2%). In all cases where vesicular and bullous changes were detected, tumor, epidermis, and dermis changes were similar. All cases were nodular stage KS lesions, whereas hyperkeratosis and serum exudation in the epidermis, marked edema in the dermis, and enlarged lymphatic vessels and chronic inflammatory response were observed.ConclusionsOur findings suggest that changes in vascular resistance occurring during tumor progression are the most important factors comprising vesiculobullous morphology.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1646397188748474

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A Bullous Variant of Kaposi's Sarcoma in an Elderly Female

Cited by 11 publications

References 16 publications

Inflammatory nuchal-occipital port-wine stains

Inflammatory nuchal-occipital port-wine stains

Lymphangioma‐like Kaposi's sarcoma: report of four cases and review

Histopathological analysis of vesicular and bullous lesions in Kaposi sarcoma

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