A Burkholderia pseudomallei Infection Imported from Eritrea to Israel

Almog, Yaniv; Yagel, Yael; Geffen, Yuval; Yagupsky, Pablo

doi:10.4269/ajtmh.16-0481

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…Melioidosis is not endemic in Israel and was previously reported in a Thai immigrant and an Eritrean immigrant in Israel. 10,16 Melioidosis was reported sporadically from different states in India, with more than 10 cases each from Karnataka, Tamil Nadu, Telangana, Kerala, Pondicherry, and West Bengal. [2][3][4][5][6] Only five cases were reported from the state of Goa, 6 and only two travel-associated imported cases from India were reported, 7,8 one of which was not definitely acquired in India.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Imported Melioidosis from Goa, India to Israel, 2018

Brosh‐Nissimov

Grupel

Abuhasira

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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A previously healthy young man presented with a chronic cavitary pulmonary infection that began while in Goa, India. Burkholderia pseudomallei was cultured from sputum samples. The infection fully resolved after prolonged antibiotic treatment. Other than traveling during the monsoon season, extensive use of well-water for water-pipe smoking of cannabis was identified as a possible risk factor for infection. This is one of the first reports of travel-associated melioidosis from India. Genomic and immunological characterization suggested that the B. pseudomallei isolate collected from the reported case exhibited limited similarity to other B. pseudomallei strains.

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Section: Discussionmentioning

confidence: 99%

Case Report: Imported Melioidosis from Goa, India to Israel, 2018

Brosh‐Nissimov

Grupel

Abuhasira

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Melioidosis is endemic in approximately 46 countries and is potentially endemic in a further 33 countries yet to report autochthonous cases (21,22). Figure 1 demonstrates areas of both known and predicted melioidosis endemicity based on environmental suitability, as well as the predicted change in prevalence of the major risk factor for infection, diabetes mellitus, by 2030 (21,23).…”

Section: Epidemiologymentioning

confidence: 99%

Human Melioidosis

2020

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SUMMARY The causative agent of melioidosis, Burkholderia pseudomallei, a tier 1 select agent, is endemic in Southeast Asia and northern Australia, with increased incidence associated with high levels of rainfall. Increasing reports of this condition have occurred worldwide, with estimates of up to 165,000 cases and 89,000 deaths per year. The ecological niche of the organism has yet to be clearly defined, although the organism is associated with soil and water. The culture of appropriate clinical material remains the mainstay of laboratory diagnosis. Identification is best done by phenotypic methods, although mass spectrometric methods have been described. Serology has a limited diagnostic role. Direct molecular and antigen detection methods have limited availability and sensitivity. Clinical presentations of melioidosis range from acute bacteremic pneumonia to disseminated visceral abscesses and localized infections. Transmission is by direct inoculation, inhalation, or ingestion. Risk factors for melioidosis include male sex, diabetes mellitus, alcohol abuse, and immunosuppression. The organism is well adapted to intracellular survival, with numerous virulence mechanisms. Immunity likely requires innate and adaptive responses. The principles of management of this condition are drainage and debridement of infected material and appropriate antimicrobial therapy. Global mortality rates vary between 9% and 70%. Research into vaccine development is ongoing.

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“…pseudomallei strain isolated from a melioidosis case diagnosed in Israel and associated with recreational travel to Goa, India. This is the third documented clinical isolate of melioidosis in Israel (8, 9) and the first case originating from India. The isolate, referred to as B.…”

Section: Announcementmentioning

confidence: 87%