A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for asthma–chronic obstructive pulmonary disease overlap in low- and middle-income countries

Zeki, Amir A.; Flayer, Cameron H.; Haczku, Angela Franciska

doi:10.1016/j.jaci.2018.11.020

Cited by 10 publications

(9 citation statements)

References 10 publications

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“…Industrial activities, vehicular emissions, and household biomass combustion are major sources of ambient particulate matter (PM) [2]. Incomplete combustion of biomass fuel and living in proximity to traffic have been associated with a high prevalence of chronic obstructive pulmonary disease (COPD) [3,4], while reductions in ambient PM have been shown to decrease the risk of COPD [5]. Therefore, it is important to elucidate the mechanism of ambient PM-induced COPD.…”

Section: Introductionmentioning

confidence: 99%

Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model

Yang

Liao

et al. 2020

Respir Res

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Background The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown. Methods Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified. Results After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide. Conclusion Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

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Section: Introductionmentioning

confidence: 99%

Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model

Yang

Liao

et al. 2020

Respir Res

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“…Exposures to signi cant levels of wild re smoke may result in obstructive lung pathology (31,32). Past studies in air pollution have focused on the effects of pollutants on the airway epithelial lining and subsequent activation of the innate immune system.…”

Section: Discussionmentioning

confidence: 99%

Sustained Effects on Lung Function in Community Members Following Exposure to Hazardous PM2.5 Levels from Wildfire Smoke

Orr

Buford

Dykstra

et al. 2020

Preprint

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Background: Extreme wildfire events are becoming more common and while the immediate risks to susceptible populations (i.e. elderly, asthmatics) are appreciated, the long-term health effects are not known. Historically, wildfire smoke exposure studies have consisted almost exclusively of retroactive health reports, including emergency department visits, hospital admissions, provider visits with emphasis on specific ICD codes. In 2017, the Seeley Lake, MT area experienced unprecedented levels of wildfire smoke from July 31 to September 18, with a daily average of 220.9 mg/m3. The aim of this study was to provide health assessments in the community as temporally close to the fires as possible and evaluate potential adverse health effects with multiple visits over two years. Additionally, the members of the community of Thompson Falls, MT were evaluated in 2018 as a comparison, due to their Northern Rockies location and 5-fold less smoke exposure during the same time period.Methods: Using the IPHARM (Improving Health Among Rural Montanans) infrastructure and experience to perform mobile health screenings, the Seeley Lake community was visited following the fires. The study resulted in the recruitment of a cohort (n=95, average age: 63 years), for a rapid response screening activity shortly following the wildland fire event, and two follow-up visits in 2018 and 2019. Results: The community experienced 35 of 49 days with >150 mg/m3 of PM2.5 which fell within the range of the Environmental Protection Agency designation of “very unhealthy”. Analysis of spirometry data found a significant decrease in lung function (FEV1/FVC ratio: forced expiratory volume in first second/forced vital capacity) and a more than doubling of participants that fell below the lower limit of normal (13.2% in 2017 to 41.7% in 2018) one year following the wildfire event, and remained decreased two years (35.9%) post exposure. In addition, observed FEV1 was significantly lower than predicted values. Conclusion: These findings suggest that wildfire smoke can have long-lasting effects on human health. As wildfires continue to increase both here and globally, understanding the health implications is vital to understanding the respiratory impacts of these events as well as developing public health strategies to mitigate the effects.

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“…Industrial activities, vehicular emissions, and household biomass combustion are major sources of ambient particulate matter (PM) [2]. Incomplete combustion of biomass fuel and living in proximity to tra c have been associated with a high prevalence of chronic obstructive pulmonary disease (COPD) [3,4], while reductions in ambient PM have been shown to decrease the risk of COPD [5]. Therefore, it is important to elucidate the mechanism of ambient PM-induced COPD.…”

Section: Introductionmentioning

confidence: 99%

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

Yang

Liao

et al. 2020

Preprint

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Background: The role of the microbiota in the pathogenesis of chronic obstructive pulmonary disease (COPD) following exposure to ambient particulate matter (PM) is largely unknown.Methods: Fifty-four male Sprague-Dawley rats were exposed to clean air, biomass fuel (BMF), or motor vehicle exhaust (MVE) for 4, 12, and 24 weeks. We performed pulmonary inflammation evaluation, morphometric measurements, and lung function analysis in rat lung at three different times points during exposure. Lung and gut microbial composition was assessed by 16S rRNA pyrosequencing. Serum lipopolysaccharide levels were measured and short-chain fatty acids in colon contents were quantified.Results: After a 24-week PM exposure, rats exhibited pulmonary inflammation and pathological changes characteristic of COPD. The control and PM exposure (BMF and MVE) groups showed similar microbial diversity and composition in rat lung. However, the gut microbiota after 24 weeks PM exposure was characterized by decreased microbial richness and diversity, distinct overall microbial composition, lower levels of short-chain fatty acids, and higher serum lipopolysaccharide.Conclusion: Chronic exposure to ambient particulate matter induces gut microbial dysbiosis and metabolite shifts in a rat model of chronic obstructive pulmonary disease.

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A burning need to redefine airways disease: Biomass smoke exposure identified as a unique risk factor for asthma–chronic obstructive pulmonary disease overlap in low- and middle-income countries

Cited by 10 publications

References 10 publications

Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model

Chronic exposure to ambient particulate matter induces gut microbial dysbiosis in a rat COPD model

Sustained Effects on Lung Function in Community Members Following Exposure to Hazardous PM2.5 Levels from Wildfire Smoke

Chronic Exposure to Ambient Particulate Matter Induces Gut Microbial Dysbiosis in a Rat COPD Model

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