A calibration method for proposed XRF measurements of arsenic and selenium in nail clippings

Gherase, Mihai R.; Fleming, David E.B.

doi:10.1088/0031-9155/56/20/n01

Cited by 21 publications

(42 citation statements)

References 14 publications

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“…3 for zinc. Using the empirical relationship [4] described earlier to fit this data resulted in best fit values of a = 0.32 AE 0.03 counts g/mg and b = 0.031 AE 0.007 mg À1 for manganese. Likewise, best fit values of a = 1.61 AE 0.25 counts g/mg and b = 0.022 AE 0.007 mg À1 resulted for zinc.…”

Section: Resultsmentioning

confidence: 99%

“…For each sample, spectra were obtained from five separate 180-s real-time irradiations. Following established protocol, [4] each of the five repeated trials were performed on the same sample. Analysis of spectra was performed as described previously in detail.…”

Section: Methodsmentioning

confidence: 99%

“…Analysis of spectra was performed as described previously in detail. [4] Briefly, spectral data were provided as count rate (counts per second) for energy channels ranging from 0 to 40 keV. To obtain the raw number of counts, count rate was multiplied by live time.…”

Section: Methodsmentioning

confidence: 99%

“…For a given mass of sample, Ka peaks from either manganese or zinc were plotted against their added concentrations, and a slope parameter was found through linear regression. Finally, these slopes were plotted against sample mass and fit with the following empirical function [4] :…”

Section: Methodsmentioning

confidence: 99%

“…[4] In the current paper, the forms of these calibration relationships are examined independently for manganese and zinc.…”

Section: Introductionmentioning

confidence: 99%

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Calibrations for measurement of manganese and zinc in nail clippings using portable XRF

2013

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A calibration method was developed to assess elemental concentrations in nail clippings, using a portable X-ray fluorescence (XRF) device. Specifically, manganese and zinc were investigated in this study. Two sets of phantom nail clipping samples were prepared, one set containing manganese and one set containing zinc. In both sets, elemental concentrations in the phantom clippings were varied from 10 to 50 mg/g, in increments of 10 mg/g. Additionally, for each concentration, five distinct masses of sample were prepared ranging from 20 to 100 mg, in increments of 20 mg. XRF spectrometry was performed with the various samples using a portable X-ray tube and detector system. Ka characteristic X-rays were detected for both manganese and zinc. Intensities of detection were plotted against added concentration, resulting in linear relationships for both manganese and zinc. The slopes of these calibration lines were then examined as a function of sample mass. An empirical function was fit to the slope-mass relationship and compared with those obtained previously from other elements. By using this XRF calibration approach, it is possible to estimate elemental concentrations in human nail clippings for a variety of elements of medical interest.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…[4] In the current paper, the forms of these calibration relationships are examined independently for manganese and zinc.…”

Section: Introductionmentioning

confidence: 99%

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Calibrations for measurement of manganese and zinc in nail clippings using portable XRF

2013

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The measurement of trace elements in human nails and nail clippings using portable X‐ray fluorescence: A review

Fleming

2021

X-Ray Spectrometry

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The copyright line for this article was changed on 24 June 2021 after original online publication.A variety of biomarkers are available for the assessment of human exposure to, and absorption of, trace elements. The measurement of trace elements in nail or nail clippings offers some benefits relative to other body sites. Typically, concentrations of elements are assessed in clippings, using high precision methods such as inductively coupled plasma mass spectrometry or instrumental neutron activation analysis. Over the last decade, portable X-ray fluorescence (pXRF) has emerged as a novel method with potential advantages for the measurement of trace elements in nail and nail clippings. This review paper examines early developments and recent work in the use of pXRF to measure elements such as As, Se, Mn, Zn, Cr, Pb, and Hg in nails and nail clippings. While initial pXRF studies were limited to the use of nail phantoms and nail clipping phantoms, more recent work has applied the pXRF method with real nail clippings and nails. Results have been promising, but a number of issues have emerged requiring additional attention. These relate to the analysis of X-ray spectra, selection of X-ray beam for excitation, method validation and normalization, and practical aspects of study design. With consideration of these issues, pXRF offers significant potential to provide a straightforward, economical, and rapid measurement approach to help improve our understanding of trace element exposure and related health outcomes.

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Quantitative analysis of human hairs and nails

Bali,

Khajuria,

Maniyar

et al. 2023

Biophys Rev

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A calibration method for proposed XRF measurements of arsenic and selenium in nail clippings

Cited by 21 publications

References 14 publications

Calibrations for measurement of manganese and zinc in nail clippings using portable XRF

Calibrations for measurement of manganese and zinc in nail clippings using portable XRF

The measurement of trace elements in human nails and nail clippings using portable X‐ray fluorescence: A review

Quantitative analysis of human hairs and nails

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