With the interest in advancing integration in the field of mixed methods research (MMR), researchers need powerful metaphors for conceiving and implementing mixing strategies. This article contributes to the field of MMR by showing how Abbott’s “fractal distinctions” provide a valuable heuristic for the application of method combinations as well as the methodological reflection of MMR. Based on its core notion, the “self-similarity” of methods approaches, I propose three heuristic guidelines: (a) deliberately seek out qualitative aspects in quantitative methods (and vice versa); (b) assume a nonessentialist, theory-oriented approach toward method integration; and (c) aim to reconcile rigor and innovation in empirical research. I discuss similarities between fractal heuristics and other conceptualizations of difference-within, including dialectical and feminist approaches to MMR.