A Calorimetric Investigation of Thermodynamic andMolecular Mobility Contributions to the Physical Stability of Two Pharmaceutical Glasses

Zhou, Deliang; Grant, David J.W.; Zhang, Geoff G. Z.; Law, Devalina; Schmitt, Eric A.

doi:10.1002/jps.20633

Cited by 58 publications

(41 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Relative to the first heat cycle, the reversing Cp values in the second heating are higher, especially in the temperature range where the exothermic plateau‐like traces were observed (T g –T m ). The reversing Cp of a pure amorphous mixture usually exhibits a significant increase as it goes through the glass transition because of the dramatic increase of its enthalpy and entropy in the super‐cooled liquid state, while for the crystalline form, the reversing Cp remains constant until the melting temperature . Therefore, in this case, the lower Cp in the first heating, following the glass transition and the gradual decrease of the Cp in the temperature range 70–120°C (for FD–Soluplus and FD–HPMCAS, respectively), suggests that the crystalline FD content within the spray‐dried mixture increases as the temperature increases.…”

Section: Resultsmentioning

confidence: 98%

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying

Tian

Caron

Healy

et al. 2014

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 98%

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying

Tian

Caron

Healy

et al. 2014

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…A consequence of this increased mobility is the tendency to revert back to a stable crystalline phase (devitrification) [72,73]. Thermodynamically, amorphous substances will inevitably devitrify, and understanding the time frame of this process is an important aspect of research directed at stabilizing these materials.…”

Section: Solid Dispersionsmentioning

confidence: 99%

Aqueous Solubility Enhancement Through Engineering of Binary Solid Composites: Pharmaceutical Applications

Moore

Wildfong

2009

J Pharm Innov

View full text Add to dashboard Cite

Limits to the aqueous solubility of emerging new chemical entities, as well as older drug molecules, represent a barrier to solid oral dosage form development. Numerous techniques are conventionally employed in aqueous solubility enhancement, although a universal strategy has proven elusive. Formation of binary solid composites, such as eutectics or amorphous solid dispersions, offers an alternative to traditional solubility enhancement techniques. The reality of these systems, however, is that very few examples have been made commercially available, ultimately stemming from a lack of understanding regarding structural and thermodynamic stability-indicating phenomena associated with higher-energy solid materials. In the present work, a comprehensive structurally based review of the fundamental solid-state properties of binary composite materials is presented. Specific emphasis is placed on current topics of research in the area of binary composite formation and the relationship to the underutilization of this technology with the pharmaceutical industry.

show abstract

“…According to the JMA equation, the crystal fraction α is independent of the means used to perform the measurements. Through the use of thermal analysis (57, 58) and X-ray diffraction (49), crystallization from the amorphous phase of several organic molecules has been described by the JMA equation.…”

Section: Applications For Active Pharmaceutical Ingredient–crystalmentioning

confidence: 99%

Second-Order Nonlinear Optical Imaging of Chiral Crystals

Kissick

Wanapun

Simpson

2011

Annual Rev. Anal. Chem.

116

122

View full text Add to dashboard Cite

Second-order nonlinear optical imaging of chiral crystals (SONICC) is an emerging technique for crystal imaging and characterization. We provide a brief overview of the origin of second harmonic generation signals in SONICC and discuss recent studies using SONICC for biological applications. Given that they provide near-complete suppression of any background, SONICC images can be used to determine the presence or absence of protein crystals through both manual inspection and automated analysis. Because SONICC creates high-resolution images, nucleation and growth kinetics can also be observed. SONICC can detect metastable, homochiral crystalline forms of amino acids crystallizing from racemic solutions, which confirms Ostwald’s rule of stages for crystal growth. SONICC’s selectivity, based on order, and sensitivity, based on background suppression, make it a promising technique for numerous fields concerned with chiral crystal formation.

show abstract

A Calorimetric Investigation of Thermodynamic andMolecular Mobility Contributions to the Physical Stability of Two Pharmaceutical Glasses

Cited by 58 publications

References 38 publications

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying

Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying

Aqueous Solubility Enhancement Through Engineering of Binary Solid Composites: Pharmaceutical Applications

Second-Order Nonlinear Optical Imaging of Chiral Crystals

Contact Info

Product

Resources

About