AMoRE (Advanced Mo-based Rare process Experiment) is an experiment to search a neutrinoless double-beta decay of 100 Mo in molybdate crystals. The neutron and muon-induced backgrounds are crucial to obtain the zero-background level (<10 −5 counts/(keV·kg·yr)) for the AMoRE-II experiment, which is the second phase of the AMoRE project, planned to run at YEMI underground laboratory. To evaluate the effects of neutron and muon-induced backgrounds, we performed Geant4 Monte Carlo simulations and studied a shielding strategy for the AMORE-II experiment. Neutroninduced backgrounds were also included in the study. In this paper, we estimated the background level in the presence of possible shielding structures, which meet the background requirement for the AMoRE-II experiment.