In connection with the need to increase the energy resources of Ukraine, it is essential to expand the areas and depths of prospecting, as well as to improve the methodology and technology of oil and gas exploration. The most promising area for the search for new oil and gas fields in Ukraine remains the Pripyat-Dneprovsko-Donetsk oil and gas province. Increasing the depth of new energy sources because of the increasing cost of exploration and deep drilling requires more accurate and efficient predictions, which should be based on a more rigorous scientific substantiation of new directions of work and the application of new efficient technologies. The article develops the concept of deep degassing of the Earth, which is of great importance for the development of modern ideas about the formation and geological history of the Pripyat-Dnieper-Donetsk oil and gas province. The authors considered the nature of oil and gas accumulation areas and their relationship with the “pipes” of deep degassing of the Earth, as well as the possibilities of structural-tectonic, lithological-geochemical and remote sensing methods in identifying new oil and gas fields in the Pripyat-Dnieper-Donetsk oil and gas province and signs of their connection with «pipes» hydrocarbon deep degassing of the Earth. To implement new methodology and technology of prospecting, exploration of oil and gas fields, the article proposes to make wider use of the modern capabilities of satellite methods, which make it possible to quickly cover large areas with multiple surveys, increase the efficiency of solving geological problems, and also significantly reduce the cost of oil and gas exploration.