2019
DOI: 10.3390/molecules24112166
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A Candidate for Multitopic Probes for Ligand Discovery in Dynamic Combinatorial Chemistry

Abstract: Multifunctionalized materials are expected to be versatile probes to find specific interactions between a ligand and a target biomaterial. Thus, efficient methods to prepare possible combinations of the functionalities is desired. The concept of dynamic combinatorial chemistry (DCC) is ideal for the generation of any possible combination, as well as screening for target biomaterials. Here, we propose a new molecular design of multitopic probes for ligand discovery in DCC. We synthesized a new Gable Porphyrin, … Show more

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Cited by 5 publications
(8 citation statements)
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“…Because the distribution and composition of the E‐ and S‐polymers obtained at the flow rate (1.0 mL min −1 ) were very close to those obtained at a flow rate of 0.5 mL min −1 (see Figures S33 and 34 in the Supporting Information), the compositions and lengths of the supramolecular polymers observed under the conditions were considered to be thermodynamic products under the solvent composition. Calibration plots were prepared by using standard polystyrenes (16 100, 1860, and 70 kDa, supplied by Tosoh) and porphyrin derivative 5 (see Figure S35, 1.162 kDa) …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Because the distribution and composition of the E‐ and S‐polymers obtained at the flow rate (1.0 mL min −1 ) were very close to those obtained at a flow rate of 0.5 mL min −1 (see Figures S33 and 34 in the Supporting Information), the compositions and lengths of the supramolecular polymers observed under the conditions were considered to be thermodynamic products under the solvent composition. Calibration plots were prepared by using standard polystyrenes (16 100, 1860, and 70 kDa, supplied by Tosoh) and porphyrin derivative 5 (see Figure S35, 1.162 kDa) …”
Section: Methodsmentioning
confidence: 99%
“…Calibration plots were prepared by using standard polystyrenes (16 100, 1860, and 70 kDa, supplied by To soh) and porphyrin derivative 5 (see Figure S35, 1.162 kDa). [34] End-capped 1Zn 2 was prepared by mixing appropriate ratios of 4Zn and 1Zn 2 in pyridine. Each mixture was concentrated under reduced pressure and the residues were dissolved in CHCl 3 to adjust the concentration of 1Zn 2 to around 3 10 À4 m.T hen, the solution (10 mL) was injected .…”
Section: Gpc Analysesmentioning
confidence: 99%
“…Satake and co-workers reported the preparation of the Gable-type porphyrin P39 bearing two imidazole-alkynyl moieties, thus becoming available to be modified via a CuAAC functionalization [37]. The A 2 BC porphyrin P37 was prepared by the condensation of dipyrromethane 13 with aldehydes 11 and 12 in the presence of trifluoroacetic acid (TFA), followed by acidic deprotection of the acetal protecting group thus affording the corresponding formyl derivative P38.…”
Section: Scheme 1 Schematic Preparation Of Microporous Porphyrin-basmentioning
confidence: 99%
“…Gable-type porphyrins P40 with a triazolyl bridge were obtained in high yields (>88%) after stirring for three days at room temperature. The authors emphasized the utility of the obtained porphyrin derivatives for the preparation of dynamic combinatorial chemistry leading to supramolecular systems by a self-assembly approach, capable of detecting interactions between a target biomaterial (e.g., proteins or nucleic acids) and a ligand [37].…”
Section: Scheme 1 Schematic Preparation Of Microporous Porphyrin-basmentioning
confidence: 99%
“…Porphyrin and its derivatives have rigid planar skeletons. The use of porphyrins as molecular building blocks is one of the typical strategies of producing a functionalized nanospace. On the other hand, 2,2′-bipyridyl is a well-known ligand for transition metal complexes . Various metal complexes having 2,2′-bipyridyl and its derivatives have attracted much attention as photosensitizers and photoredox catalysts. Combined compounds of porphyrins and 2,2′-bipyridyl or 1,10-phenanthrolinyl derivatives have also been reported, in which multinuclear complexes were prepared. However, cyclic arrays connected alternately with 2,2′-bipyridyl moieties and porphyrins are limited, except for our cyclic trimer Zn-3 Me (Figure ) connected through 2,2′-bipyridyl moieties and Zn porphyrins .…”
Section: Introductionmentioning
confidence: 99%