2016
DOI: 10.1007/s00702-016-1540-7
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A candidate gene investigation of methylphenidate response in adult attention-deficit/hyperactivity disorder patients: results from a naturalistic study

Abstract: Attention-deficit/hyperactivity disorder (ADHD) is a common childhood onset neuropsychiatric disorder with a complex and heterogeneous symptomatology. Persistence of ADHD symptoms into adulthood is common. Methylphenidate (MPH) is a widely prescribed stimulant compound that may be effective against ADHD symptoms in children and adults. However, MPH does not exert satisfactory effect in all patients. Several genetic variants have been proposed to predict either treatment response or adverse effects of stimulant… Show more

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Cited by 14 publications
(17 citation statements)
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“…?’, and the alternative responses were ‘yes’ and ‘no’. The patients’ treating physicians provided a separate form confirming the ADHD diagnosis and with information regarding past and present treatment with stimulants 16 and other psychopharmacological agents.…”
Section: Methodsmentioning
confidence: 99%
“…?’, and the alternative responses were ‘yes’ and ‘no’. The patients’ treating physicians provided a separate form confirming the ADHD diagnosis and with information regarding past and present treatment with stimulants 16 and other psychopharmacological agents.…”
Section: Methodsmentioning
confidence: 99%
“…As a result, clinicians often use a trial-and-error approach based on different types of medication or on titration of dosages to find the best fit for each patient 13 . It seems clear that identifying accurate predictors of response to medication would be beneficial for clinical practice 14 16 .…”
Section: Introductionmentioning
confidence: 99%
“…However, there is a need for studies which help to decide whether the same genetic variants influence genetic vulnerability to multiple (psychiatric and somatic) phenotypes (horizontal/independent pleiotropy), or the genetic variants influence vulnerability to one phenotype, and that phenotype in turn causes the other phenotype (Paaby and Rockman, 2013;Verbanck et al, 2018;Vink et al, 2020;Du Rietz et al, 2021a;Zhu, 2021). et al, 2008. No association in adults: Mick et al, 2006;Contini et al, 2010;Bonvicini et al, 2016;Hegvik et al, 2016.…”
Section: Therapeutic Aspectsmentioning
confidence: 99%
“…A summary of pharmacogenetic studies ( Mick et al, 2006 ; Kooij et al, 2008 ; Nemoda et al, 2009 ; Ramoz et al, 2009 ; Contini et al, 2010 , 2011 , 2012 ; Johnson et al, 2013 ; Yang et al, 2013 ; Fang et al, 2015 ; Hegvik et al, 2016 ; Gomez-Sanchez et al, 2017 ; Pagerols et al, 2017 ; Angyal et al, 2018 ; Huang et al, 2018 ; Naumova et al, 2019 ; Bonvicini et al, 2020 ; Gul et al, 2021 ; Yuan et al, 2021 ) assessing the most investigated candidate genes is provided in Table 2 .…”
Section: Introductionmentioning
confidence: 99%