“…Δ 9 -THC (Lyman et al, 1989;Arévalo-Martín et al, 2003;Pryce et al, 2003 andMaresz et al, 2007), CBD (Kozela et al, 2011;Mecha et al, 2013;Pryce et al, 2014), or with additional cannabinoids, e.g. ' 8 -THC (Wirguin et al, 1994), cannabigerol quinone (Granja et al, 2012;Carrillo-Salinas et al, 2014), WIN55,212-2 (Pryce et al, 2003;Mestre et al, 2009;de Lago et al, 2012), HU-210 (Aarabi et al, 2011), and inhibitors of the endocannabinoid inactivation (Loría et al, 2010). It remains, however, to be established whether lower doses of these botanical drug substances are immunosuppressive as previous studies have related Δ 9 -THCinduced immunosuppression at doses above 5 mg/kg to cannabimimetic effects (Croxford et al 2008).…”