A carbon ion beam irradiated MWCNT/AuNPs composite sensor for a sensitive assay of purine-nucleosides of DNA

Abstract

Sensor for purine nucleosides has been developed using irradiation with high energy carbon ion beam.

Improving Functional Behavior of MCM‐41 by Encapsulating MnO2 Nanorods towards Simultaneous Determination of Purine Bases in DNA Samples

“…Major physiological functions such as cellular energy transduction, blood circulation, control of coronary and cerebral circulation, and neurotransmitter release are regulated by nucleic acids [3][4][5]. [3][4][5] Amongst the constituent nitrogenous bases, adenine (AD) and guanine (GU) are two principal purine bases [6,7]. [3][4][5] Amongst the constituent nitrogenous bases, adenine (AD) and guanine (GU) are two principal purine bases [6,7].…”

“…Their concentration levels serve as an indicator of many life threatening diseases such as cancer, HIV infections, epilepsy, etc. Thus the determination of nitrogenous bases in physiological fluids is quintessential from clinical and therapeutics perspectives [2][3][4][5][6][7]. Any kind of discrepancy in the constituent nitrogenous bases of nucleic acids leads to an erroneous gene expression like mutations or abnormal functioning of the human body.…”

“…[3][4][5] Amongst the constituent nitrogenous bases, adenine (AD) and guanine (GU) are two principal purine bases [6,7]. So far various techniques have been implemented for determination of GU and AD such as high performance liquid chromatography, mass spectrometry, capillary electrophoresis, flow injection-chemiluminescence, ion-pairing liquid chromatography, fluorescence and electrochemical methods [2][3][4][5][6][7]. Thus the determination of nitrogenous bases in physiological fluids is quintessential from clinical and therapeutics perspectives [2][3][4][5][6][7].…”

“…Any kind of discrepancy in the constituent nitrogenous bases of nucleic acids leads to an erroneous gene expression like mutations or abnormal functioning of the human body. Thus the determination of nitrogenous bases in physiological fluids is quintessential from clinical and therapeutics perspectives [2][3][4][5][6][7]. So far various techniques have been implemented for determination of GU and AD such as high performance liquid chromatography, mass spectrometry, capillary electrophoresis, flow injection-chemiluminescence, ion-pairing liquid chromatography, fluorescence and electrochemical methods [2][3][4][5][6][7].…”

“…Thus the determination of nitrogenous bases in physiological fluids is quintessential from clinical and therapeutics perspectives [2][3][4][5][6][7]. So far various techniques have been implemented for determination of GU and AD such as high performance liquid chromatography, mass spectrometry, capillary electrophoresis, flow injection-chemiluminescence, ion-pairing liquid chromatography, fluorescence and electrochemical methods [2][3][4][5][6][7]. Electrochemical methods based on the oxidation of GU and AD at modified electrodes are highly advantageous on account of their low cost, high sensitivity, selectivity and user friendly operational system [2][3][4][5].…”