A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

Ye, Binglin; Hu, Wenting; Yu, Guocan; Yang, Huang; Gao, Bingqiang; Ji, Jian; Mao, Zhengwei; Huang, Feihe; Wang, Weilin; Ding, Yuan

doi:10.1021/acsnano.4c03172

ACS Nano

2024

DOI: 10.1021/acsnano.4c03172

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A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

Binglin Ye,

Wenting Hu,

Guocan Yu

et al.

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Cited by 8 publications

References 60 publications

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How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?

Cao,

Zhao,

Miao

et al. 2024

Adv Healthcare Materials

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The rapid development of self‐assembly technology during the past few decades has effectively addressed plenty of the issues associated with carrier‐based drug delivery systems, such as low loading efficiency, complex fabrication processes, and inherent toxicity of carriers. The integration of nanoscale delivery systems with self‐assembly techniques has enabled efficient and targeted self‐administration of drugs, enhanced bioavailability, prolonged circulation time, and controllable drug release. Concurrently, the limitations of single‐mode cancer treatment, including low bioavailability, poor therapeutic outcomes, and significant side effects, have highlighted the urgent need for multimodal combined antitumor therapies. Set against the backdrop of multimodal cancer therapy, this review summarizes the research progress and applications of a large number of self‐assembled drug delivery platforms, including natural small molecule self‐assembled, carrier‐free self‐assembled, amphiphilic polymer‐based self‐assembled, peptide‐based self‐assembled, and metal‐based self‐assembled nano drug delivery systems. This review particularly analyzes the latest advances in the application of self‐assembled nano drug delivery platforms in combined antitumor therapies mediated by chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, and immunotherapy, providing innovative research insights for further optimization and expansion of self‐assembled nano drug delivery systems in the clinical translation and development of antitumor combined therapy.

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How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?

Cao,

Zhao,

Miao

et al. 2024

Adv Healthcare Materials

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Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy

Guo,

Gao,

et al. 2024

Advanced Science

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Breast cancer, the most prevalent malignancy among women, frequently exhibits high HER2 expression, making HER2 a critical therapeutic target. Traditional treatments combining the anti‐HER2 antibody trastuzumab with immunotherapy face limitations due to toxicity and tumor microenvironment immunosuppression. This study introduces an innovative strategy combining HER2‐targeting peptides with the photosensitizer (PSs) pyropheophorbide‐a (Pha) via a gelatinase‐cleavable linker, forming self‐assembling nanoparticles. These nanoparticles actively target breast cancer cells and generate reactive oxygen species (ROS) under near‐infrared light, effectively degrading HER2 proteins. Upon internalization, the linker is cleaved, releasing Pha‐PLG and enhancing intracellular photodynamic therapy (PDT). The Pha‐PLG molecules self‐assemble into nanofibers, prolonging circulation, boosting immune induction, and activating CD8+ T cells, thus promoting a robust anti‐tumor immune response. In vivo, studies confirm superior biosafety, tumor targeting, and HER2 degradation, with increased cytotoxic T cell activity and improved antitumor immunity. This integrated strategy offers a promising new avenue for breast cancer treatment.

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Photo‐Triggered ROS‐Responsive Supramolecular Nanoprodrugs for Targeted and Synergistic Chemo/Photodynamic/Gas Therapy

Shi,

Ma,

Yang

et al. 2024

Chemistry A European J

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Photo‐triggered ROS‐responsive supramolecular nanoprodrugs (BNN6@GBTC NPs) are constructed via supramolecular self‐assembly of amphiphilic prodrug molecule (GBTC) and NO donor (BNN6). BNN6@GBTC NPs possess good stability, ROS responsiveness, and selective HepG2 cells targetability via overexpressed galactose receptors on the cell membrane. When BNN6@GBTC NPs are taken up by HepG2 cells, they can generate ROS upon light irradiation, which can not only be used for photodynamic therapy, but also cleave the thioketal linkage to release camptothecin for chemotherapy. Meanwhile, BNN6 triggering release NO for gas therapy. BNN6@GBTC NPs enable targeted and synergistic chemo/photodynamic/gas therapy, which results in reduced damage to normal cells and enhanced anti‐cancer efficacy in vitro. This work provides a novel approach for the design of nanoprodrugs based on supramolecular self‐assembly to achieve the multimodal synergistic anti‐cancer therapy.

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A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

Cited by 8 publications

References 60 publications

How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?

How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?

Precise HER2 Protein Degradation via Peptide‐Conjugated Photodynamic Therapy for Enhanced Breast Cancer Immunotherapy

Photo‐Triggered ROS‐Responsive Supramolecular Nanoprodrugs for Targeted and Synergistic Chemo/Photodynamic/Gas Therapy

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