A Cascade Sonogashira Cross‐Coupling‐Substitution‐Elimination Reaction for the Synthesis of Linear Conjugated Dienynes

Abstract

The engagement in tandem of well‐known organic reactions such as the Pd‐catalyzed Sonogashira cross‐coupling reaction, nucleophilic substitution and elimination reactions, enables the synthesis of otherwise difficult to obtain linear dienynes, in moderate to high yields. This retrosynthetic approach opens new ways to prepare highly conjugated alkenes and alkynes. Furthermore, ionic liquids are suitable solvents to perform the cascade reaction and recycle the metal catalysts.

Chemometric tools for kinetic investigations of a homogeneously catalysed Sonogashira cross-coupling reaction in flow

“…This approach is similar to a recent publication. 63 The product concentration profiles at varying catalyst concentration can be found in the ESI †. This half-order dependence on the catalyst concentration has already been described in literature for palladium complexes in Heck reactions, which are related to the Sonogashira cross-coupling reactions.…”

“…This approach is similar to a recent publication. 63 The product concentration profiles at varying catalyst concentration can be found in the ESI. † This half-order dependence on the catalyst concentration has already been described in…”