A Case against Spiral Ligament Atrophy as a Cause of Ménière’s Disease

Harris, Jeffrey P.; Keithley, Elizabeth M.

doi:10.1159/000057791

Cited by 1 publication

(1 citation statement)

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“…Thus, hydrops may be a marker for Ménière_s disease, with the primary pathology occurring in the SL or the SV. Previous studies have yielded mixed results regarding the association of atrophy of the SL or SV with Ménière_s disease, and one study reported no evidence of SL atrophy in Ménière_s disease, using length and width measurements of the SL in archival human temporal bones (Harris and Keithley 2002).…”

Section: Introductionmentioning

confidence: 99%

Unbiased Stereological Estimation of the Spiral Ligament and Stria Vascularis Volumes in Aging and Ménière’s Disease Using Archival Human Temporal Bones

Ishiyama

Tokita

López

et al. 2006

JARO

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The present study applies the unbiased stereological technique-Cavalieri principle to measure the volumes of the stria vascularis (SV) and the spiral ligament (SL) using postmortem archival human temporal bones from normal young and older subjects and subjects with Ménière_s disease. Normative data was obtained from subjects without ages ranging from 15 to 84 years old who had no history of audiovestibular disease (N = 25). For comparison purposes, the normative specimens were divided into three groups: group 1 (n = 8) had ages ranging from 15 to 38 years old, average age = 23.9; group 2 (n = 8) had ages ranging from 51 to 59 years old, average age = 55.1; group 3 (n = 9) had ages ranging from 64 to 84 years old, average age = 74.3. The average SV volume of group 3 (0.479 mm 3 ) was significantly lower than that of group 1 (0.705 mm 3 ) (p G 0.0005) and was significantly lower than that of group 2 (0.603 mm 3 ) (p = 0.01). The average SL volume of group 3 (8.42 mm 3 ) was significantly lower than that of group 1 (9.54 mm 3 ) (p G 0.05), but was not significantly lower than that of group 2 (8.58 mm 3 ). Five subjects with Ménière_s disease, confirmed by histopathological examination (ages ranging from 63 to 91 years old, average age = 73.4), were studied. The average SV volume in Ménière_s subjects (0.378 mm 3 ) was significantly lower than age-matched controls (p G 0.05). The average SL volume in Ménière_s subjects (7.01 mm 3 ) was also significantly lower than age-matched controls (p G 0.05). The SV and SL volumes were unaffected by gender. The present study demonstrates for the first time the use of the unbiased stereological technique-Cavalieri principle-as a reliable and efficient method to obtain volumetric estimates of the SV and the SL by using archival human temporal bone specimens.

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Section: Introductionmentioning

confidence: 99%