The implementation of Industry 4.0 technology has developed rapidly. Despite its development, Indonesia is still nascent and requires some implementation monitoring in its priority industries. This study aims to design a system for assessing the readiness of implementing Industry 4.0 in priority manufacturing industries in Indonesia. A Fuzzy Inference System framework with six main dimensions has been developed to assess the level of readiness for Industry 4.0 in priority manufacturing industries. The six assessment dimensions are Legal Consideration, Products and Service, Manufacturing and Operations, Strategy and Organization, Supply Chain, and Business Model. These dimensions have been developed into a complete assessment system for evaluating the level of readiness for implementing Industry 4.0. Validation of the system has shown that the multi-dimensional assessment system can provide appropriate assessment results to assess the level of readiness for Industry 4.0 in priority manufacturing industries.