A case control association study of <i>ACE</i> gene polymorphism (I/D) with hypertension in Punjabi population from Faisalabad, Pakistan

Hussain, Misbah; Awan, Fazli Rabbi; Gujjar, Amna; Hafeez, Shakir; Islam, Mehboob

doi:10.1080/10641963.2017.1356842

Cited by 30 publications

(19 citation statements)

References 21 publications

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“…Some of these peptides may inhibit the angiotensin-converting enzyme (ACE), a transmembrane zinc metallopeptidase that is related to hypertension (Seppo et al, 2003;Beermann and Hartung, 2013;Zoumpopoulou, 2016). Inhibiting ACE is an important strategy for controlling clinical hypertension (Hussain et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage

Zhou

Huo

Kwok

et al. 2019

Journal of Dairy Science

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Lactobacillus helveticus H9 is a probiotic bacterium originating from traditional Tibetan kurut. It has high angiotensin-converting enzyme-inhibitory (ACEI) and antihypertensive activities. We aimed to evaluate the effects of L. helveticus H9 supplementation in yogurt fermentation and storage. We monitored changes of multiple parameters over 28 d of storage at 4°C; namely, pH, titratable acidity, free amino groups, ACEI activity, physical properties, volatile flavor compounds, and sensory quality. Supplementation of L. helveticus H9 enhanced fermented milk acidification and proteolysis, resulting in a shorter fermentation time. The H9 treatment significantly increased the ACEI activity of the fermented milks. Fifteen key volatile flavors were detected by solid-phase microextraction-gas chromatography-mass spectrometry across all samples. More alcohols, aldehydes, and nitrogenous compounds, especially acetoin and benzaldehyde, were detected in the H9-supplemented fermented milks. The human sensory scores for flavor and texture, but not appearance, were lower for the H9-supplemented fermented milks, particularly beyond 2 wk of cold storage. Our results will be of interest to the dairy industry for developing novel functional dairy products.

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Section: Introductionmentioning

confidence: 99%

Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage

Zhou

Huo

Kwok

et al. 2019

Journal of Dairy Science

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“…However, this association is variable when diabetes co-occurs with CVDs. Our previous study has also showed the association of ACE I/D polymorphism with hypertension [13]. To further refine our results and to add more data, the current study was carried out with more sample number to mainly focus on the association of ACE I/D polymorphism with development of diabetes in cardiac patients.…”

Section: Introductionmentioning

confidence: 79%

“…This gene consists of 26 exons and encodes 2 transcript variants [9]. Insertion/Deletion (I/D) polymorphism (rs4340) consisting of 287 bp Alu repeats in intron 16 of ACE is extensively studied polymorphism, involved in controlling the plasma ACE activity [10] and found associated with various metabolic diseases [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Hussain

Abbas

Ahmed

et al. 2019

Exp Clin Endocrinol Diabetes

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Angiotensin converting enzyme (ACE), as part of renin angiotensin aldosterone system, is involved in blood pressure regulation and control several physiological functions. Insertion/Deletion (I/D) polymorphism of ACE has pronounced effects on development of metabolic diseases like diabetes, cardiovascular diseases (CVDs) and hypertension. However, association of I/D polymorphism with risk of diabetes in CVD patients is not known. The aim of present study was to check the association of ACE I/D polymorphism with risk of diabetes in subjects with CVD. For this, 531 subjects were sampled and divided into 3 groups; G1-H (healthy controls, n=117), G2-CN (cardiac patients without diabetes, n=271) and G3-CD (cardiac patients with diabetes, n=143). Genotyping of ACE I/D polymorphism was done by polymerase chain reaction. Allelic and genotypic frequencies were in Hardy Weinberg Equilibrium (χ2=0.11, p>0.05) and revealed high prevalence of I allele (55%) among all groups. However, II genotype was more common (37%) in G3-CD group. Level of glucose was also higher in subjects with II genotype than DD genotype (12.6±6.3 mmol/L vs. 9.7±5.1 mmol/L). Logistic regression analysis revealed that ACE II genotype increase the risk of diabetes in CVD patients by ~2 times [OR=1.94, CI: 1.24–3.01, p=0.03]; however, this association did not reach the significance level when adjusted for age and gender. In conclusion, ACE I/D polymorphism influence the risk of diabetes in CVD patients and ACE II increases this risk by ~2 fold.

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“…Linie auf ACE, welchem durch die Umwandlung von Angiotensin I zu II eine Schlüsselrolle zukommt. In einer aktuellen Studie aus Indien wurde ein I/D-Polymorphismus (I/D: Insertion/Deletion) des ACE-Gens bei 61 % der untersuchten Hypertoniepatienten im Vergleich zu 41 % bei den gesunden Mitgliedern der Kontrollgruppe beobachtet [45]. Dabei zeigte sich eine signifikante Assoziation des DD-ACE-Genotyps mit einem höheren systolischen Blutdruck.…”

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Kochsalz in der Ernährung

Jehle¹,

Beckert²,

Arendt³

et al. 2018

Aktuel Ernahrungsmed

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While salt, a vital mineral resource, plays an undeniably influential role in maintaining body functions, the general population tends to unknowingly consume too much of it on a daily basis. The DEGS-Study (German Adult Health Survey), which focuses on documenting the salt intake of the German population, shows that the median salt intake of 70?% of the participating women and 80?% of the men lies above the DGE?s (German Society for Nutrition) recommended daily dose of 6?g. The WHO similarly recommends a salt consumption of no more than 5?g per day (approximately a teaspoon of salt) as a target value in its guidelines. Salt plays an important role in regulating the renin angiotensin pathway (also known as the RAA pathway), which, in turn, maintains volume, sodium chloride and blood pressure homeostasis within the body. Understanding this process becomes increasingly important, as arterial hypertension is still a significant cause of death worldwide. The data of numerous large, randomized, controlled studies is evidence for the harmful effects of a high sodium chloride consumption on the human body. Current research is focused on further understanding the regulation of salt depots in the skin as well as the effect of sodium chloride on the microbiome of the intestinal tract.

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A case control association study of ACE gene polymorphism (I/D) with hypertension in Punjabi population from Faisalabad, Pakistan

Cited by 30 publications

References 21 publications

Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage

Effects of applying Lactobacillus helveticus H9 as adjunct starter culture in yogurt fermentation and storage

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Kochsalz in der Ernährung

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