A Case-Control Study Assessing the Impact of Nonventilated Hospital-Acquired Pneumonia on Patient Outcomes

Micek, Scott T.; Chew, Bethany; Hampton, Nicholas; Kollef, Marin H.

doi:10.1016/j.chest.2016.04.009

Cited by 109 publications

(109 citation statements)

References 23 publications

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“…This study was a retrospective analysis of all persons diagnosed with NVHAP during a single year at a single center. Prior aspects of this analysis have been described elsewhere [7]. Briefly, the study was conducted between 1 January 2014 and 31 December 2014.…”

Section: Study Overviewmentioning

confidence: 99%

Viruses are prevalent in non-ventilated hospital-acquired pneumonia

Shorr

Zilberberg²,

Micek

et al. 2017

Respiratory Medicine

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Section: Study Overviewmentioning

confidence: 99%

Viruses are prevalent in non-ventilated hospital-acquired pneumonia

Shorr

Zilberberg²,

Micek

et al. 2017

Respiratory Medicine

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“…[44][45][46] More recently, the FilmArray RP has been employed to demonstrate that more than 24% of nonventilated hospital-acquired pneumonia (HAP) episodes were associated with respiratory virus infection alone or concomitant viral and bacterial infection. 47 This type of information could have important implications in terms of modifying or deescalating antibiotic therapy. 44 A new Luminex NxTAG Respiratory Pathogen Panel (NxTAG-RPP, Austin, TX) has been introduced as a highthroughput system that can detect nucleic acid from 21 respiratory viruses, including all pathogens detected by the FilmArray RP except B. pertussis plus Legionella pneumophila and human bocavirus.…”

Section: New Diagnostic Technologies Multiplex Real-time Polymerase Cmentioning

confidence: 99%

Ventilator-Associated Pneumonia: The Role of Emerging Diagnostic Technologies

Kollef

2017

Semin Respir Crit Care Med

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Antibiotic resistance has emerged as a key determinant of outcome in patients with serious infections along with the virulence of the underlying pathogen. Within the intensive care unit (ICU) setting, ventilator-associated pneumonia (VAP) is a common nosocomial infection that is frequently caused by multidrug-resistant bacteria. Antimicrobial resistance is a growing challenge in the care of critically ill patients. Escalating rates of antibiotic resistance add substantially to the morbidity, mortality, and cost related to infection in the ICU. Both gram-positive organisms, such as methicillin-resistant and vancomycin-intermediate, and gram-negative bacteria, including , species, carbapenem-resistant , such as the carbapenemase-producing bacteria, and extended spectrum β-lactamase organisms, have contributed to the escalating rates of resistance seen in VAP and other nosocomial infections. The rising rates of antimicrobial resistance have led to the routine empiric administration of broad-spectrum antibiotics even when bacterial infection is not documented. Moreover, there are several new broader-spectrum antibiotics that have recently become available and others scheduled for approval in the near future. The challenge to ICU clinicians is how to most effectively utilize these agents to maximize patient benefits while minimizing further emergence of resistance. Use of rapid diagnostics may hold the key for achieving this important balance. There is an urgent need for integrating the administration of new and existing antibiotics with the emerging rapid diagnostic technologies in a way that is both cost-effective and sustainable for the long run.

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“…Findings from a multi-centred study from the United States suggests that 18.8% of patients with NV-HAP required transfer into the intensive care unit [11]. NV-HAP also results in a prolonged hospital stay and increased patient morbidity and mortality [12,13]. However, NV-HAP is both underreported and understudied with most research conducted on VAP, thereby prompting recent calls for an urgent need to prioritise research on NV-HAP [14].…”

Section: Introductionmentioning

confidence: 99%

Strategies to reduce non-ventilator-associated hospital-acquired pneumonia: A systematic review

Mitchell

Russo

Cheng

et al. 2019

Infection, Disease & Health

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Background: Point prevalence studies identify that pneumonia is the most common healthcare associated infection. However, non-ventilator associated healthcare associated pneumonia (NV-HAP) is both underreported and understudied. Most research conducted to date, focuses on ventilator associated pneumonia. We conducted a systematic review, to provide the latest evidence for strategies to reduce NV-HAP and describe the methodological approaches used. Methods: We performed a systematic search to identify research exploring and evaluating NV-HAP preventive measures in hospitals and aged-care facilities. The electronic database Medline was searched, for peer-reviewed articles published between 1st January 1998 and 31st August 2018. An assessment of the study quality and risk of bias of included articles was conducted using the NewcastleeOttawa Scale. Results: The literature search yielded 1551 articles, with 15 articles meeting the inclusion criteria. The majority of strategies for NV-HAP prevention focussed on oral care (n Z 9). Three studies evaluated a form of physical activity, such as passive movements, two studies used

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A Case-Control Study Assessing the Impact of Nonventilated Hospital-Acquired Pneumonia on Patient Outcomes

Cited by 109 publications

References 23 publications

Viruses are prevalent in non-ventilated hospital-acquired pneumonia

Viruses are prevalent in non-ventilated hospital-acquired pneumonia

Ventilator-Associated Pneumonia: The Role of Emerging Diagnostic Technologies

Strategies to reduce non-ventilator-associated hospital-acquired pneumonia: A systematic review

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