A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype

Minocherhomji, Sheroy; Athalye, Arundhati S.; Madon, Prochi F.; Kulkarni, Deepak; Uttamchandani, Shonali A.; Parikh, Firuza R.

doi:10.1016/j.fertnstert.2008.05.071

Cited by 77 publications

(115 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…general population [8][9][10][11]. This suggests that CPs are associated with infertility and should not be ignored [6,12].…”

Section: Introductionmentioning

confidence: 99%

“…This suggests that CPs are associated with infertility and should not be ignored [6,12]. In addition, increased rates of recurrent spontaneous abortions and embryonic losses and other adverse obstetric histories were also found to be correlated with CPs [10,13]. Nevertheless, the etiological mechanisms for these phenomena remain largely elusive.…”

Section: Introductionmentioning

confidence: 99%

“…Differences in the incidences of CPs have been discovered between infertile men and women [6,10]. The high incidence of CPs in men is associated with the presence of Y chromosome variants.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Zhang

Wang

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose Chromosomal polymorphisms (CPs) have been reported to be associated with infertility; however, their effects on the outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) are still controversial. In this retrospective study, we aimed to evaluate the effect of CPs on IVF/ICSI-ET outcomes. Methods To investigate whether CPs affected the outcomes of fresh IVF/ICSI-ET cycles in a Chinese population, we evaluated infertile couples with male carriers of CPs (n = 348), infertile couples with female carriers (n = 99), and unaffected couples (n = 400) who had received their first treatment cycles in our hospital between January 2013 and March 2015.Results CPs in either male or female carriers seemed to have adverse effects on IVF/ICSI-ET outcomes. CPs in male carriers affected outcomes mainly by decreasing the rates of fertilization, embryo cleavage, good quality embryos, clinical pregnancies, ongoing pregnancies, and deliveries as well as increasing the biochemical pregnancy rate (P < 0.05); CPs in female carriers affected outcomes only by lowering the embryo cleavage rate (P < 0.05). The mean fertilization rate of couples with male CP carriers undergoing IVF was significantly lower than that in those undergoing ICSI (61.1 versus 66.5 %, respectively; P = 0.0004). Conclusions Our data provide evidence for the involvement of CPs in the poor outcomes of fresh IVF/ICSI-ET cycles in a Chinese population. The use of ICSI might improve outcomes by increasing the fertilization rate for men with CPs.

show abstract

“…general population [8][9][10][11]. This suggests that CPs are associated with infertility and should not be ignored [6,12].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Zhang

Wang

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Cavkayta et al [25] have reported that the rate of chromosomal anomaly is far higher in the men with moderate to severe oligo-asthenospermia than in general population, and chromosomal anomaly often leads to male spermatogenic dysfunction and reduces male reproductive ability. However, this study indicated that the rate of chromosomal anomaly was higher in slight oligo-astheno-spermia group (11.82 %) than in moderate to severe oligo-astheno-spermia group (6.58 %), which was caused by that chromosomal anomaly mainly was chromosomal polymorphism in slight oligo-astheno-spermia group and chromosomal polymorphism did not markedly affect male fertility [22,23].…”

Section: Type and Incidence Of Chromosomal Anomaly In Infertile Menmentioning

confidence: 60%

“…Most scholars believe no clear association between chromosome polymorphism and infertility [21,22]. However, some scholars believe that chromosome polymorphism can cause carriers to give birth to offspring with unbalanced translocation karyotype or to have a history of adverse pregnancy or delivery outcomes [23]. Autosomal structural abnormalities (1.36 %, 203/14965) took the third place and mainly were balanced translocation and Robertsonian translocation.…”

Section: Type and Incidence Of Chromosomal Anomaly In Infertile Menmentioning

confidence: 99%

Karyotype analysis in large-sample infertile couples living in Central China: a study of 14965 couples

Liu

Kong

et al. 2013

J Assist Reprod Genet

View full text Add to dashboard Cite

Objective To explore that it is necessary to routinely detect chromosomes in fertile couples, we detected peripheral blood lymphocyte karyotype in 14965 infertile couples living in Central China and analyzed the incidence and type of chromosomal anomaly. Methods G-banding karyotype analysis of peripheral blood lymphocytes was performed in 14965 couples who went to the outpatient department of our reproductive medical center for counseling on infertility between January 2004 and December 2011. Semen analysis was performed three times in all the men from the 14965 couples. Results The rate of chromosomal anomaly in the 14965 infertile couples was 3.84 % (1150/29930). The rate of chromosomal anomaly in the men from 14965 couples was 6.84 % (1024/14965) and in the women 0.84 % (126/14965). The rates of chromosomal anomaly were 1.69 % in normal semen group, 11.82 % in light oligoastheno-spermis group, 6.58 % in moderate to severe oligastheno-spermia group and 17.26 % in azoospermia group. Conclusion Since the rates of chromosomal anomaly are 1.69 % and 11.82 % even in normal semen group and light oligo-astheno-spermia group, respectively, it is necessary to detect peripheral blood lymphocyte karyotype in all infertile couples.

show abstract

Meta‐analysis of the association between chromosomal polymorphisms and outcomes of embryo transfer following in vitro fertilization and/or intracytoplasmic sperm injection

Yin

Chen

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Background The outcomes of in vitro fertilization and/or intracytoplasmic sperm injection (IVF/ICSI) are contradictory among individuals with chromosomal polymorphisms. Objectives To assess whether chromosomal polymorphisms affect the outcomes of assisted reproductive technologies. Search strategy Four online databases were searched from inception to September 18, 2017, using terms including “chromosomal polymorphisms” and “In vitro fertilization.” Selection criteria The meta‐analysis included studies published in any language on IVF/ICSI outcomes in relation to male and/or female chromosomal polymorphisms (n=8). Data collection and analysis Data were extracted using a predesigned form. The IVF/ICSI outcomes were then pooled and their heterogeneity assessed. Main results Male chromosomal polymorphisms showed lowered values for fertilization rate (odds ratio [OR] 1.29, 95% confidence interval [CI] 1.09–1.54; P=0.004); cleavage rate (OR 2.65, 95% CI 1.88–3.72; P<0.001); good quality embryos rate (OR 1.26, 95% CI 1.15–1.39; P<0.001); and live birth rate (OR 1.42, 95% CI 1.10–1.83; P=0.007). By contrast, early spontaneous abortion rate, clinical pregnancy rate, and ongoing pregnancy rate were not affected in this group. No relationship was found between IVF/ICSI outcomes and female chromosomal polymorphisms. Conclusions Male, but not female, chromosomal polymorphisms were associated with lowered values for some outcomes of IVF/ICSI.

show abstract

A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype

Cited by 77 publications

References 42 publications

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

The effect of chromosomal polymorphisms on the outcomes of fresh IVF/ICSI–ET cycles in a Chinese population

Karyotype analysis in large-sample infertile couples living in Central China: a study of 14965 couples

Meta‐analysis of the association between chromosomal polymorphisms and outcomes of embryo transfer following in vitro fertilization and/or intracytoplasmic sperm injection

Contact Info

Product

Resources

About