A Case-Control Study of Alzheimer's Disease in Japan – Significance of Life-Styles

Kondo, Kiyotaro; Niino, Minehisa; Shido, Koichi

doi:10.1159/000106741

Cited by 138 publications

(147 citation statements)

References 2 publications

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“…Certainly premorbid decline can cause reduction in activities in years preceding onset of clinical dementia, as demonstrated by Fabrigoule et al (20) in an incidence study of dementia in subjects who were followed for 3 years. This premorbid effect could influence relationships with physical (33), mental (32,34), and social activities (19). A study by Zabar and colleagues † † found no difference in activities between caseand highly selected control-group members participating in the Baltimore Longitudinal Study of aging.…”

Section: Discussionmentioning

confidence: 99%

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

Friedland

Fritsch

Smyth

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

376

276

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The development of Alzheimer's disease (AD) later in life may be reflective of environmental factors operating over the course of a lifetime. Educational and occupational attainments have been found to be protective against the development of the disease but participation in activities has received little attention. In a casecontrol study, we collected questionnaire data about 26 nonoccupational activities from ages 20 to 60. Participants included 193 people with probable or possible AD and 358 healthy controlgroup members. Activity patterns for intellectual, passive, and physical activities were classified by using an adaptation of a published scale in terms of ''diversity'' (total number of activities), ''intensity'' (hours per month), and ''percentage intensity'' (percentage of total activity hours devoted to each activity category). The control group was more active during midlife than the case group was for all three activity categories, even after controlling for age, gender, income adequacy, and education. The odds ratio for AD in those performing less than the mean value of activities was 3.85 (95% confidence interval: 2.65-5.58, P < 0.001). The increase in time devoted to intellectual activities from early adulthood (20 -39) to middle adulthood (40 -60) was associated with a significant decrease in the probability of membership in the case group. We conclude that diversity of activities and intensity of intellectual activities were reduced in patients with AD as compared with the control group. These findings may be because inactivity is a risk factor for the disease or because inactivity is a reflection of very early subclinical effects of the disease, or both.case-control study ͉ dementia ͉ epidemiology ͉ leisure ͉ recreation

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Section: Discussionmentioning

confidence: 99%

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

Friedland

Fritsch

Smyth

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

376

276

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“…There was little more influence to give body activity by men than in the case of women. Kondoh et al (1995) conducted a survey on the remaining teeth in the aged and reported that the loss of teeth is related to the progression of dementia. It has also been reported that the loss of teeth is a risk factor for senile Alzheimer's dementia.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Study on Improving the QOL and Oral Conditions of the Aged-Part 1: The Relationship between the Status of Tooth Preservation and QOL

Yoshida¹,

Hatanaka²,

Imaki³

et al. 2001

J. Physiol. Anthropol.

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In part 1 of this epidemiological study, a survey was conducted for all senior citizens aged 70 and over who resided in a mountainous village in the mid-section of Hyogo Prefecture. It focused on the relationship among the number of existing teeth, life environment, health status, and activities of daily living; and the correlation between oral status and QOL was analyzed. The daily activities of individuals were compared between those having one or more teeth and others who were totally edentulous. Subsequently, it was found that fo r bo th m ales a nd fem ales, the odds r ati o was significantly high for the dentulous individuals, in comparison with edentulous individuals, to exhibit a behavior indicative of a better QOL (such as "opportunity for conversation with family members or others)", "regular physical activities", and "attend meetings or group outings"). The result of this survey indicates that the presence of teeth is very closely related to one's daily activities. It was concluded that preventing tooth loss is vital for maintaining the masticatory function; so to prevent tooth loss, periodontal disease must be averted.

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“…58 Tooth loss is also suggested to be a risk factor of Alzheimer's disease. Having no teeth, together with a lack of mental and physical activity, poor education, and previous head injuries, very greatly increases the probability of falling ill. 59 In these pathologies, hearing defects may likely be connected with poor results in speech audiometry.…”

Section: Dental Pathologies and Hearingmentioning

confidence: 99%

Hearing and stomatognathic system: Searching for a link

Baliński¹,

Morawska-Kochman²,

Bochnia³

2017

Dent. Med. Probl.

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Acoustic vibrations reach the inner ear fluids in 3 integral ways: through the air, bone, and soft tissue. The final stimulation of the hearing receptor is recognized as the result of various interactions appearing between them. Air conduction is best described as the most efficient mode of auditory stimulation. Soft tissue and bone conduction (including dentaural hearing), being frequently underestimated in the complicated process of hearing, are still less examined. Clinical observations prove that dental health may have a direct influence on hearing. Additionally, hearing improvement after dental treatment is of a permanent nature.This review presents a hypothesis and supporting literature review that dental disorders may contribute to disturbances in the excitation and/or the transmission of vibrations through the bone to the hearing receptor. Dissociation in the relationship between stimuli reaching the cochlea simultaneously in 3 modes may have a negative impact on hearing acuity.

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A Case-Control Study of Alzheimer's Disease in Japan – Significance of Life-Styles

Cited by 138 publications

References 2 publications

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

Epidemiological Study on Improving the QOL and Oral Conditions of the Aged-Part 1: The Relationship between the Status of Tooth Preservation and QOL

Hearing and stomatognathic system: Searching for a link

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