A case-control study of aplastic anemia

Linet, Martha S.; Markowitz, Jan A.; Sensenbrenner, Lyle L.; Warm, S; Weida, Sally; Natta, Mark L. Van; Szklo, Moysés

doi:10.1016/0145-2126(89)90025-8

Cited by 17 publications

(11 citation statements)

References 36 publications

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“…Although benzene exposure is clearly correlated to the development of aplastic anaemia, data that correlate development of AA to cigarette smoke are rare. Linet et al (1989) failed to find a significant correlation between aplastic anaemia and cigarette smoke in a case control study involving 59 patients. One possible explanation is that the chronic exposure to benzene may be enough to produce statistically significant data on leukaemia.…”

Section: A P L a S T I C A N A E M I A A N D H A E M A T O X I C I T Ymentioning

confidence: 92%

Anaemia and cigarette smoking

Leifert

2008

Int J Lab Hematology

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Summary Cigarette smoking causes numerous diseases that are associated with anaemia but the resulting low haemoglobin levels may be counterbalanced by increased red blood cell production caused by chronic exposure to carbon monoxide from cigarette smoke. Diverse mechanisms are involved in influencing the development or the course of anaemic disease in smokers. This article presents an evaluation of the current literature on the impact of cigarette smoking on various forms of anaemia.

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Section: A P L a S T I C A N A E M I A A N D H A E M A T O X I C I T Ymentioning

confidence: 92%

Anaemia and cigarette smoking

Leifert

2008

Int J Lab Hematology

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“…In Western populations, the age distribution of incident cases is bimodal with a peak during young adulthood and another in the elderly (Bottiger & Westerholm, 1972; Linet et al , 1989; Mary et al , 1990).…”

mentioning

confidence: 99%

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

Muir¹,

Chilvers

Harriss³

et al. 2003

Br J Haematol

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Summary. Aplastic anaemia is a rare but serious disorder with a high morbidity and mortality rate. The causes of aplastic anaemia are, for the most part, unknown. We report on the hypothesis that aplastic anaemia may be caused by occupational and/or environmental exposures to certain chemicals. The UK Aplastic Anaemia Study was an interview-based case-control study covering the whole of Great Britain. Those patients diagnosed between 1 July 1993 and 20 October 1997, aged £75 years and born and diagnosed in the UK were eligible for the study. Two hundred eligible cases of aplastic anaemia were compared with 387 age-and sex-matched controls. A number of occupational exposures showed increases in risk. In a multivariate model of these exposures the odds ratios (ORs) for solvents/ degreasing agents, pesticides and radiation were >2 and statistically significant. Reported chemical treatment of houses within 5 years of diagnosis had a significantly raised risk for adults [OR ¼ 2AE51, 95% confidence interval (CI) 1AE02-12AE01], particularly for woodworm treatment (OR ¼ 5AE1, 95% CI 1AE5-17AE4). This study identified significant risks associated with self-reported exposure to solvents, radiation and pesticides in the workplace. Self-reported chemical treatment of houses was also associated with an increased risk of developing aplastic anaemia, in keeping with previous literature.

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“…10 In fact, several reports have implied that the viral illness was a precipitating event in some cases of AA. [11][12][13] The relationship between hepatitis and the subsequent development of AA has been documented in over 200 cases. 11,[14][15][16] Although HAV and HBV have been associated with AA in a small number of patients, most cases are related to non-A, non-B viral hepatitis.…”

mentioning

confidence: 99%

“…[11][12][13] The relationship between hepatitis and the subsequent development of AA has been documented in over 200 cases. 11,[14][15][16] Although HAV and HBV have been associated with AA in a small number of patients, most cases are related to non-A, non-B viral hepatitis. 17,18 The median survival of untreated patients with AA is 3 to 6 months, with only 20% surviving beyond 1 year.…”

mentioning

confidence: 99%

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

Safadi

Ilan

et al. 2001

Bone Marrow Transplant

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Summary:Viral infection has been shown to induce aplastic anemia, unidentified types of hepatitis being the most common cause for aplastic anemia-associated viral hepatitis. The survival rate for this group of patients after bone marrow transplantation with stem cells from an HLAmatched sibling is not well known. The aim of this study was to determine the prevalence of hepatitis G virus (HGV) and transfusion transmitted virus (TTV) infection in non-A, non-B, non-C hepatitis associated-aplastic anemia (HAAA) patients, and to define the role of bone marrow transplantation (BMT) as a therapeutic modality for this disease.

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A case-control study of aplastic anemia

Cited by 17 publications

References 36 publications

Anaemia and cigarette smoking

Anaemia and cigarette smoking

The role of occupational and environmental exposures in the aetiology of acquired severe aplastic anaemia: a case control investigation

Lack of known hepatitis virus in hepatitis-associated aplastic anemia and outcome after bone marrow transplantation

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