A Case-Control Study of Soft-Tissue Sarcoma

Zahm, Shelia Hoar; Blair, Aaron; Holmes, Frederick F.; Boysen, C D; Robel, Robert J.

doi:10.1093/oxfordjournals.aje.a115388

Cited by 57 publications

(43 citation statements)

References 52 publications

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“…The results of this study suggest a direct association between risk of STS and BMI in men and women and no relation with height, in agreement with the findings of Zahm et al (1989). Overweight and obesity are major public health issues and are associated with several chronic diseases and shorter life expectancy (Manson et al, 1987), probably through multiple biological mechanisms.…”

Section: Discussionsupporting

confidence: 89%

“…The results of this study suggest a direct association between risk of STS and BMI in men and women and no relation with height, in agreement with the findings of Zahm et al (1989). Summary The relation between body mass (BMI) and soft-tissue sarcoma (STS) risk was evaluated in a case-control study from Northern Italy based on 217 incident STS and 1297 hospital controls.…”

Section: Discussionsupporting

confidence: 85%

“…

SUBJECTS AND METHODS

Data were derived from a case-control study of STS, conducted between 1983 and 1998 in the greater Milan area and the province of Pordenone, northern Italy (Serraino et al, 1991;Tavani et al, 1997).

Cases were 217 patients (113 men, median age 52 years, range 21-79; and 104 women, median age 54 years, range 16-79) with histologically confirmed incident (i.e.

…”

mentioning

confidence: 99%

“…A population-based case-control study (Zahm et al, 1989) conducted in Kansas, USA and based on 133 cases showed that the risk of soft-tissue sarcoma (STS) increased with adult body weight, the odds ratio (OR) being 2.0 for people weighing more than 200 pounds. To provide further information on this issue, we analysed data from a large case-control study conducted in Italy.…”

mentioning

confidence: 99%

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Body weight and risk of soft-tissue sarcoma

et al. 1999

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A population-based case-control study (Zahm et al, 1989) conducted in Kansas, USA and based on 133 cases showed that the risk of soft-tissue sarcoma (STS) increased with adult body weight, the odds ratio (OR) being 2.0 for people weighing more than 200 pounds. To provide further information on this issue, we analysed data from a large case-control study conducted in Italy. SUBJECTS AND METHODSData were derived from a case-control study of STS, conducted between 1983 and 1998 in the greater Milan area and the province of Pordenone, northern Italy (Serraino et al, 1991;Tavani et al, 1997).Cases were 217 patients (113 men, median age 52 years, range 21-79; and 104 women, median age 54 years, range 16-79) with histologically confirmed incident (i.e. diagnosed within the year preceding the interview) STS (International Classification of Diseases IX Edition ICD-171) admitted to the cancer institutes and major teaching and general hospitals of the areas under surveillance.Controls were 1297 patients (792 men, median age 55 years, range 17-79; and 505 women, median age 57 years, range 17-79) admitted to the same network of hospitals for acute, nonneoplastic and non-immune-related conditions. Of the comparison group, 15% were admitted for traumas, 27% for other orthopaedic disorders (such as low back pain and disc diseases), 29% for acute surgical conditions (such as acute appendicitis or strangulated hernia), and 28% for other miscellaneous illnesses (such as ear, nose and throat, eye, dental or skin disorders). On average, fewer than 4% of the eligible cases and controls refused the interview.Trained interviewers used a structured questionnaire to collect data on socio-demographic characteristics, anthropometric measures (self-reported weight and height), personal and family history of selected medical conditions, a few selected occupational and environmental exposures, smoking status and consumption of alcohol, coffee and selected dietary items. Data analysisBody mass index (BMI) was computed according to Quetelet's index (weight height -2 , kg m -2 ), which is essentially an indicator of weight unrelated to height (Benn, 1971). Odds ratios (OR) with their corresponding 95% confidence intervals (CI) were derived using unconditional multiple logistic regression analysis, fitted by the method of maximum likelihood (Breslow and Day, 1980). The regression models included terms for study centre, year of recruitment, age (8 levels plus a continuous term) and education. Table 1 gives the distribution of STS cases and controls by sex according to age and BMI, and the OR of STS according to BMI. The risk of STS rose with BMI, and the OR was 3.28 in subjects with a BMI > 30 compared to those with BMI ≤ 20. The OR was 3.49 for men and 3.26 for women. The risk estimates did not change after further adjustment for employment in agriculture and radiation therapy: the OR became 3.41 and 3.53 respectively for men and women with BMI > 30 compared to those with BMI ≤ 20. RESULTSA separate analysis for broad categories of anatomical sit...

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Section: Discussionsupporting

confidence: 89%

“…The results of this study suggest a direct association between risk of STS and BMI in men and women and no relation with height, in agreement with the findings of Zahm et al (1989). Summary The relation between body mass (BMI) and soft-tissue sarcoma (STS) risk was evaluated in a case-control study from Northern Italy based on 217 incident STS and 1297 hospital controls.…”

Section: Discussionsupporting

confidence: 85%

“…

SUBJECTS AND METHODS

Data were derived from a case-control study of STS, conducted between 1983 and 1998 in the greater Milan area and the province of Pordenone, northern Italy (Serraino et al, 1991;Tavani et al, 1997).

Cases were 217 patients (113 men, median age 52 years, range 21-79; and 104 women, median age 54 years, range 16-79) with histologically confirmed incident (i.e.

…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Body weight and risk of soft-tissue sarcoma

et al. 1999

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“…A study of relatives of patients with soft tissue sarcoma has shown that there is a 1.9-fold increased risk of prostate cancer in these relatives, although this is not statistically signi®cant (95% CI 0.7 ± 5.1). 34 The search for the gene(s) predisposing to familial prostate cancer…”

Section: Familial Aggregation Of Prostate Cancer With Other Cancersmentioning

confidence: 99%

Genetic predisposition to prostate cancer

Eeles

1999

Prostate Cancer Prostatic Dis

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Prostate cancer has been known to run in families for about 40 years and epidemiological studies have demonstrated an increased risk to close relatives of cases. This risk rises markedly when the closeness and number of cases in a cluster increases. There has been considerable debate about the genetic model, in particular whether there is a commoner lower penetrance (moderately increased risk of the disease due to the gene(s)) in addition to contribution from high risk genes. For the ®rst time, molecular results are starting to emerge, indicating the location of high risk genes. These have shown that there is evidence for more than one site of a high risk, gene two sites on chromosome 1 and one on chromosome X. These do not account for all clusters of prostate cancer cases and further genes remain to be discovered. This article also outlines the contribution of the numerous collaborators in the British Prostate Group to the UK Familial Prostate Cancer Study.

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Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen

Mack¹

1995

Cancer

161

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Background. Malignant neoplasms of the structural tissues, consisting mostly of soft tissue sarcomas, are morphologically diverse and rarely treated for epidemiologic purposes as individual entities. Our understanding to date of the pattern of occurrence of sarcomas is based largely on reports of limited individual clinic experience or case‐control studies, each driven by a single hypothesis, and there have been virtually no descriptions according to specific morphologic type. Methods. The accumulated coverage of the SEER populations offers an opportunity to correct this deficit. Each of the diagnoses has been reported and coded using a single set of rules and described in relation to the population at risk in terms of age, sex, race, calendar period, anatomic location, and outcome. In addition, each morphologic type has been compared with each of the others with respect to the pattern of occurrence and survival. Results. For most of the individual morphologic entities, the pattern of occurrence is specific and unlike other patterns. Differences according to anatomic site, age, sex, race, and period‐specific survival were found. Partly because of changes in diagnostic criteria over the years, differences in secular trend, other than that for Kaposi's sarcoma, could not be verified. Although some types of sarcoma may have important genetic determinants, there is evidence of environmental causation in others; for some varieties both genetic and environmental factors may operate. There is no evidence of improvements in survival. Conclusions. The most likely basis for the observed patterns are morphology‐specific differences in etiology and growth phase. Each of the entities should be considered etiologically distinct and should be studied individually whenever possible.

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A Case-Control Study of Soft-Tissue Sarcoma

Cited by 57 publications

References 52 publications

Body weight and risk of soft-tissue sarcoma

Body weight and risk of soft-tissue sarcoma

Genetic predisposition to prostate cancer

Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen

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