A Case-Control Study of the Lymphatic Phenotype of Yellow Nail Syndrome

Cousins, Emma; Cintolesi, V.; Vass, Laurence; Stanton, A.W.B.; Irwin, A. G.; Heenan, Susan; Mortimer, Peter

doi:10.1089/lrb.2018.0009

Cited by 14 publications

(8 citation statements)

References 22 publications

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“…Pericardial effusion and ascites can be seen [ 5 ]. Impairment of lymphatic drainage has been considered to play a primary role in the pathogenesis of YNS, which was recently confirmed by a case-control study that utilized lymphoscintigraphy for patients with YNS and healthy controls [ 6 ]. Maldonado et al reported that about one third of YNS cases with pleural fluid showed chylothorax, which also indicates that dysregulation of lymphatics is involved in the pathogenesis of YNS [ 4 ].…”

Section: Discussionmentioning

confidence: 96%

An autopsy case report of yellow nail syndrome coincided with primary biliary cholangitis

Kato

Akagawa

Kusaka

et al. 2021

Respiratory Medicine Case Reports

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Section: Discussionmentioning

confidence: 96%

An autopsy case report of yellow nail syndrome coincided with primary biliary cholangitis

Kato

Akagawa

Kusaka

et al. 2021

Respiratory Medicine Case Reports

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“…In a study of 17 YNS patients, lymphoscintigraphy demonstrated lymphatic insufficiency [ 6 ]. Lymph uptake and transport were reduced by (41%-44%) in axillary and ilioinguinal lymph nodes [ 6 ]. The lymphoscintigraphy was not applied in our hospital.…”

Section: Discussionmentioning

confidence: 99%

“…Aging can participate in lymph drainage dysfunction without anatomical problems. [ 6 ] In addition, increased microvascular permeability leads to protein leak and edema. YNS may be associated with malignant and non-malignant cases including immunodeficiencies [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Amlodipine as a Suggested Cause of Yellow Nail Syndrome: A Case Report

Houri¹,

Al-Tarcheh²,

Zghaier³

et al. 2022

Cureus

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Yellow nail syndrome (YNS) is a rare disorder initially described in 1964. It is characterized by a classical triad: yellow nails, lymphedema, and respiratory manifestations. We present a 71-year-old woman who presented with progressive dyspnea. Medical history includes hypertension treated with amlodipine. Examination showed bilateral lower extremity non-pitting edema, yellowish discoloration of nails, and bilateral pleural effusion. Thoracentesis demonstrated chylous effusion. The presumptive diagnosis was YNS. Assuming amlodipine as a cause of interstitial edema, it was stopped, and the symptoms improved gradually. After two months, amlodipine was restarted externally, and the dyspnea relapsed. Amlodipine was discontinued again. After two years of amlodipine cessation, the patient remained well without symptoms. The progression and resolution of symptoms point to amlodipine as a suggested cause of YNS. Paying attention to the prescribed drugs was the key to diagnosing and resolving serious complications.

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“…Clinical characteristics are the same as those of primary lymphedema, most commonly occurring on lower limbs, although facial edema and upper limb lymphedema have been rarely reported [16,23]. Prevalence of pleural effusions is approximately 14%-16% in YNS, with the prevalent clinical manifestation being chronic cough, and bronchiectasias are present in approximately 44% of patients [2].…”

Section: Associated Conditionsmentioning

confidence: 99%

Nails: The Window to the Nose? Update on Yellow Nail Syndrome

Vollono

Chessa

Bruno

et al. 2020

Dermatol Pract Concept

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Background: Yellow nail syndrome is a rare condition characterized by typical nail alterations and variable presence of lymphedema and respiratory disease. The pathogenesis is still obscure, with most of the literature deriving from case reports and few investigations. The most reported respiratory conditions associated with yellow nail syndrome are pleural effusion and bronchiectasis, whereas association with rhinosinusitis is rarer. Objectives: To describe a case of yellow nail syndrome and to provide a literature review regarding this condition, discussing pathogenetic hypothesis, associated conditions, and therapeutic options. Patients/Methods: A 49-year-old man presented with arrested growth and alterations of his nails, without any history of previous trauma or inflammation but with a severe nasal septum deviation and a history of chronic rhinosinusitis. A diagnosis of yellow nail syndrome was made. Results: Six months after undergoing rhinoseptoplasty and treatment with oral vitamin E, the patient’s nails were cured. Conclusions: This case emphasizes the role of the dermatologist in detecting systemic conditions. The correct diagnosis led to complete resolution of both nail alterations and associated respiratory condition.

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A Case-Control Study of the Lymphatic Phenotype of Yellow Nail Syndrome

Cited by 14 publications

References 22 publications

An autopsy case report of yellow nail syndrome coincided with primary biliary cholangitis

An autopsy case report of yellow nail syndrome coincided with primary biliary cholangitis

Amlodipine as a Suggested Cause of Yellow Nail Syndrome: A Case Report

Nails: The Window to the Nose? Update on Yellow Nail Syndrome

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