A case for the therapeutic use of perfluorocarbon in pulmonary atelectasis

Bali, S.; Morgan, Gareth J.; Nyman, Andrew; Turcu, Simona; Durward, Andrew

doi:10.1136/thoraxjnl-2016-208619

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…Perfluorocarbon is an inert, organofluorine compound of high density that is rapidly dissolved and evaporates at an interface with air. 1 Due to the high density it diffuses into alveoli and mobilizes secretions, debris, and blood that subsequently "floats" on the perfluorocarbon facilitating clearance. 1 Well aerated lung areas rapidly clear perfluorocarbon as it evaporates.…”

Section: Use Of Tracheal Packing and Perfluorocarbon In Life-threatenmentioning

confidence: 99%

“…1 Due to the high density it diffuses into alveoli and mobilizes secretions, debris, and blood that subsequently "floats" on the perfluorocarbon facilitating clearance. 1 Well aerated lung areas rapidly clear perfluorocarbon as it evaporates. The benefit of using radio-opaque PFC overusing radiotranslucent substances is that poorly aerated areas can be visualized on X-rays and X-rays can be used to gauge PFC clearance.…”

Section: Use Of Tracheal Packing and Perfluorocarbon In Life-threatenmentioning

confidence: 99%

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Use of tracheal packing and perfluorocarbon in life‐threatening pulmonary hemorrhage on ECMO

Kleine‐Brueggeney

Nyman

James

2020

Pediatric Pulmonology

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Section: Use Of Tracheal Packing and Perfluorocarbon In Life-threatenmentioning

confidence: 99%

Section: Use Of Tracheal Packing and Perfluorocarbon In Life-threatenmentioning

confidence: 99%

Use of tracheal packing and perfluorocarbon in life‐threatening pulmonary hemorrhage on ECMO

Kleine‐Brueggeney

Nyman

James

2020

Pediatric Pulmonology

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“…In cell culture, Blood Substitute acts as hemoglobin, but with the ability to passively accept all respiratory gases because it is constantly equilibrated with air in our ventilated, open system perfusion platform that eliminates the need for large scale equipment to charge PFC emulsions with 95% oxygen. The Blood Substitute is similar to gas-carrier PFC liquids used in neonatal liquid ventilation (Hirschl et al, 1995;Shaffer et al, 1999;Hirschl, 2017;Eichenwald et al, 2020;Kohlhauer et al, 2020), liquid breathing (Kylstra, 1974), lung atelectasis (Henrichsen et al, 2012;Bali et al, 2017), organ preservation (Matsumoto and Kuroda, 2002;Matsumoto, 2005), and artificial blood (Riess, 2005;Spiess, 2009Spiess, , 2010, but contains only one molecule with two elements, carbon and fluorine. When used in clinical or in vivo research applications, PFCs do not mix with any bodily fluids or enter tissues, and do not support microbial growth.…”

Section: Introductionmentioning

confidence: 99%

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

Shoemaker

Zhang

Atlas

et al. 2020

Front. Mol. Biosci.

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Remarkable advances in three-dimensional (3D) cell cultures and organ-on-a-chip technologies have opened the door to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. The challenges regarding oxygen delivery, throughput, assay multiplexing, and experimental complexity are addressed to ensure that perfused 3D cell culture organ-on-a-chip models become a routine research tool adopted by academic and industrial stakeholders. To move the field forward, we present a throughput-scalable organ-on-a-chip insert system that requires a single tube to operate 48 statistically independent 3D cell culture organ models. Then, we introduce in-well perfusion to circumvent the loss of cell signaling and drug metabolites in otherwise one-way flow of perfusate. Further, to augment the relevancy of 3D cell culture models in vitro, we tackle the problem of oxygen transport by blood using, for the first time, a breathable hemoglobin analog to improve delivery of respiratory gases to cells, because in vivo approximately 98% of oxygen delivery to cells takes place via reversible binding to hemoglobin. Next, we show that improved oxygenation shifts cellular metabolic pathways toward oxidative phosphorylation that contributes to the maintenance of differentiated liver phenotypes in vitro. Lastly, we demonstrate that the activity of cytochrome P450 family of drug metabolizing enzymes is increased and prolonged in primary human hepatocytes cultured in 3D compared to two-dimensional (2D) cell culture gold standard with important ramifications for drug metabolism, drug-drug interactions and pharmacokinetic studies in vitro.

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Case-based discussion from the neonatal intensive care unit: a case of an intentional oesophageal intubation

Jamieson

Boyd

Tan

et al. 2017

Thorax

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Tracheal agenesis (TA) is a rare congenital defect consisting of complete or partial absence of the trachea below the larynx. Antenatal diagnosis is challenging, and most cases are detected in the postnatal period. Airway management of such cases, particularly in the absence of antenatal diagnosis, can be challenging. Various methods of management have been described but with limited success, and overall prognosis remains very poor. We present an unexpected case of TA, highlighting management issues and diagnostic methods.

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A case for the therapeutic use of perfluorocarbon in pulmonary atelectasis

Cited by 4 publications

References 5 publications

Use of tracheal packing and perfluorocarbon in life‐threatening pulmonary hemorrhage on ECMO

Use of tracheal packing and perfluorocarbon in life‐threatening pulmonary hemorrhage on ECMO

A 3D Cell Culture Organ-on-a-Chip Platform With a Breathable Hemoglobin Analogue Augments and Extends Primary Human Hepatocyte Functions in vitro

Case-based discussion from the neonatal intensive care unit: a case of an intentional oesophageal intubation

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