A case of a teenage boy with eosinophilic gastroenteritis with esophageal involvement developing a hemorrhagic duodenal ulcer

Yamazaki, Kenji; Sakashita, Tatsuya; Iwata, Hitoshi; Mizutani, Taku; Matsuura, Kazuaki; Sugiyama, Tomohiko; Sato, Hiroyuki; Ando, Nobuhiro; Iwata, Koichi; Imose, Motoaki; Shimizu, Shogo; Imamura, Atsushi; Araki, Hiroshi; Sugihara, Junichi

doi:10.1007/s12328-015-0572-0

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…A PubMed search with the keywords "hematemesis," "bleeding," "melena," "eosinophilic esophagitis," "eosinophilic gastritis," "eosinophilic gastroenteritis," and "eosinophilic colitis" was conducted and revealed 16 publications dating between 2007 and 2020 (3)(4)(5)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). A total of 26 patients, between 1 day and 75 years of age, who presented with UGIB or LGIB and received an EGID diagnosis, were identified.…”

Section: Review Of the Literaturementioning

confidence: 99%

Upper Gastrointestinal Bleeding as the First Presentation of Eosinophilic Gastrointestinal Disease

et al. 2020

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Gastrointestinal bleeding is a rare but potentially life-threatening manifestation of eosinophilic gastrointestinal disorders (EGIDs). Here, we describe a case series comprising 5 pediatric patients between 7 and 12 years of age, who presented to the emergency department with hematemesis and were subsequently diagnosed with EGID. Accompanying allergic history, peripheral eosinophilia, and total IgE elevation were common. Despite a more severe presentation, response to medical and dietary therapy was favorable. A comprehensive review of the literature revealed 26 other cases with similar findings that reinforced the importance of prompt recognition and early dietary and immunomodulating therapy in the control of this disease.

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Section: Review Of the Literaturementioning

confidence: 99%

Upper Gastrointestinal Bleeding as the First Presentation of Eosinophilic Gastrointestinal Disease

et al. 2020

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“…Regarding bleeding peptic ulcer with eosinophilic gastroenteritis, six cases were found by searching for "eosinophilic gastroenteritis"and "bleeding ulcer"in Pubmed (Table 2). [5][6][7][8][9][10] There are more male cases than female cases,and most cases are young. In one case, control of bleeding by clipping was insufficient, then additional interventional radiology was conducted.…”

Section: Discussionmentioning

confidence: 99%

A successful treatment case of refractory hemorrhagic ulcer with eosinophilic gastritis by endoscopic hand suturing

et al. 2023

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A 78‐year‐old man was admitted to our hospital with a tarry stool. Esophagogastroduodenoscopy identified tiny oozing on the greater curvature at the antrum. Despite repeated endoscopic hemostasis by coagulation and clipping, rebleeding occurred. On the third rebleeding, we performed endoscopic hand suturing to completely close the ulcer surface. Biopsy showing massive infiltration of eosinophils at the ulcer edge indicated eosinophilic gastritis. After the endoscopic closure by endoscopic hand suturing, the patient had no symptoms of bleeding thereafter and was discharged 19 days after the procedure by taking oral prednisolone. The patient remained well and was continuously treated with a small dose of steroids in outpatient. This is the first case report of the successful application of endoscopic hand suturing to a refractory hemorrhagic ulcer. Further accumulation of clinical experiences is desired to confirm the usefulness of this technique for the prevention of refractory ulcer bleeding.

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“…Endoscopic findings associated with non-EoE EGIDs include shallow mucosal erosions but also deep ulcers, perforated ulcers, diffuse friability, thickened folds, nodularity or granularity, mucosal edema and redness, as well as normalappearing mucosa (7,14,18,21,56,58,59,61,(64)(65)(66)(67)(68)(69)(70)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88). In a multicenter retrospective cohort of 317 children and 56 adult patients with non-EoE EGIDs, the most common finding was normal appearance of the mucosa in the stomach (66%), duodenum (83%), jejunum (67%), and ileum (81%) (7).…”

Section: Statement 10 In Patients With Eoc the Colonoscopy Findings I...mentioning

confidence: 99%

“…QoE: Low, Agreement: 100% Summary of Evidence Imaging studies such as abdominal ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and contrast series do not directly contribute to the diagnosis of non-EoE EGIDs but can provide data on structural involvement (muscular, serosal) and follow disease status during treatment. Findings include thickening of the GI wall, gastric or intestinal folds, hypertrophy of the pylorus, thickening of the mesentery, dilated bowel loops or narrowing of the bowel, enlarged inflammatory mesenteric lymph nodes, and ascites (54,(57)(58)(59)61,62,65,67,82,94).…”

Section: Are Any Imaging Studies Helpful In the Evaluation Of Patient...mentioning

confidence: 99%

Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis

Papadopoulou,

Amil‐Dias,

Auth

et al. 2024

J. pediatr. gastroenterol. nutr.

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INTRODUCTION: Eosinophilic Gastrointestinal Disorders beyond Eosinophilic Esophagitis (non-EoE EGIDs) are rare chronic inflammatory disorders of the gastrointestinal (GI) tract. Diagnosis is based on clinical symptoms and histologic findings of eosinophilic inflammation after exclusion of a secondary cause or systemic disease. Currently, no guidelines exist for the evaluation of non-EoE EGIDs. Therefore, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) formed a task force group to provide consensus guidelines for childhood non-EoE EGIDs. METHODS: The working group was composed of pediatric gastroenterologists, adult gastroenterologists, allergists/immunologists, and pathologists. An extensive electronic literature search of the MEDLINE, EMBASE, and Cochrane databases was conducted up to February 2022. General methodology was used in the formulation of recommendations according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to meet current standards of evidence assessment. RESULTS: The guidelines provide information on the current concept of non-EoE EGIDs, disease pathogenesis, epidemiology, clinical manifestations, diagnostic and disease surveillance procedures, and current treatment options. Thirty-four statements based on available evidence and 41 recommendations based on expert opinion and best clinical practices were developed. CONCLUSION: Non-EoE EGIDs literature is limited in scope and depth, making clear recommendations difficult. These consensus-based clinical practice guidelines are intended to assist clinicians caring for children affected by non-EoE EGIDs and to facilitate high-quality randomized controlled trials of various treatment modalities using standardized, uniform disease definitions.

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A case of a teenage boy with eosinophilic gastroenteritis with esophageal involvement developing a hemorrhagic duodenal ulcer

Cited by 8 publications

References 16 publications

Upper Gastrointestinal Bleeding as the First Presentation of Eosinophilic Gastrointestinal Disease

Upper Gastrointestinal Bleeding as the First Presentation of Eosinophilic Gastrointestinal Disease

A successful treatment case of refractory hemorrhagic ulcer with eosinophilic gastritis by endoscopic hand suturing

Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis

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