A case of a tiny (1.2cm) non-functioning pancreatic endocrine tumor invading the main pancreatic duct successfully treated by laparoscopy-assisted distal pancreatectomy with splenectomy

Very few cases of primary neuroendocrine tumors of the main pancreatic duct have been reported. This paucity has hampered an accurate description of the distinctive clinical and pathological features of these tumors and the correct evaluation of the diagnostic and therapeutic problems which they may raise. We report here five additional cases in order to underline the clinical, histological, and immunohistochemical features of this tumor entity. There were three male and two female, aged 43-72 years; in all patients, but one, who presented with epigastric pain, the diagnosis was made after the incidental discovery of a dilatation of the main pancreatic duct. The preoperative diagnosis was ductal adenocarcinoma in one case, IPMN in one case and neoplastic stenosis of unknown etiology in four cases. Surgical resection was performed in all cases. The diagnosis of neuroendocrine tumor was made at histological examination. All lesions were small, ranging from 5 to 15 mm. They had a predominantly intramural growth. The growth pattern was nodular in three cases, circumferential in two; there was no intra-luminal component. All cases were well-differentiated neuroendocrine neoplasms of low histological grade (G1); four cases expressed serotonin. One case was associated with regional lymph node metastases. All cases were cured by surgery alone; no recurrence was observed at the end of the follow-up period. In conclusion, despite their rarity, primary neuroendocrine tumors of the main pancreatic duct deserve recognition and must be considered in the etiological diagnosis of ductal stenosis.

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Primary neuroendocrine tumors of the main pancreatic duct: a rare entity

Walter

Hervieu

Adham

et al. 2011

Virchows Arch

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A resected case of preoperatively diagnosed glucagonoma of the pancreas using EUS-FNA

Usui¹,

Kato²,

Nobuoka³

et al. 2010

Journal of the Japan Pancreas Society

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A Case of Non-Functional Pancreatic Neuroendocrine Tumor Showing Atypical Imaging Findings

Hosokawa¹,

Takeuchi²,

Otsuka³

et al. 2011

Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)

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A case of a tiny (1.2cm) non-functioning pancreatic endocrine tumor invading the main pancreatic duct successfully treated by laparoscopy-assisted distal pancreatectomy with splenectomy

Cited by 4 publications

References 14 publications

Primary neuroendocrine tumors of the main pancreatic duct: a rare entity

Primary neuroendocrine tumors of the main pancreatic duct: a rare entity

A resected case of preoperatively diagnosed glucagonoma of the pancreas using EUS-FNA

A Case of Non-Functional Pancreatic Neuroendocrine Tumor Showing Atypical Imaging Findings

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