A case of acquired haemophilia A in a 70‐year‐old post COVID‐19 vaccine

Lemoine, Chantal; Giacobbe, Alaina; Bonifacino, Eliana; Karapetyan, Lilit; Seaman, Craig D.

doi:10.1111/hae.14442

Cited by 17 publications

(21 citation statements)

References 10 publications

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“…Six cases of AHA following COVID-19 vaccination have occurred worldwide. [7][8][9][10] Interestingly, most of them involved elderly patients with multiple comorbidities. All presented with bleeding within 1-3 weeks after receiving the mRNA vaccine, either Pfizer or Moderna (mRNA-1273).…”

Section: Discussionmentioning

confidence: 99%

“…Six cases of AHA following COVID-19 vaccination have occurred worldwide 7–10. Interestingly, most of them involved elderly patients with multiple comorbidities.…”

Section: Discussionmentioning

confidence: 99%

“…Life-threatening bleeding such as a large intramuscular haematoma, haemarthrosis and even a haemothorax were observed. A few of these were treated with rFVIIa and activated prothrombin complex concentrate (aPCC) to control the bleeding 8 9. One patient passed away due to an acute gallbladder rupture with active arterial bleeding.…”

Section: Discussionmentioning

confidence: 99%

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Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine

et al. 2022

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Acquired haemophilia A (AHA) is a rare bleeding disorder with high morbidity and mortality, but it is eminently treatable if diagnosis and treatment are prompt. We report a case of AHA in Southeast Asia following the administration of the Pfizer-BioNTech COVID-19 vaccine. A man in his 80s developed multiple bruises 2 weeks after his first dose of the COVID-19 vaccine. Diagnosis was delayed due to his cognitive impairment and low clinical suspicion. This led to a representation with worsening ecchymosis, a left thigh haematoma and symptomatic anaemia. Laboratory testing was notable for an isolated prolongation of the activated partial thromboplastin time, which remained uncorrected in the mixing test. Further testing confirmed the presence of factor VIII (FVIII) inhibitors and low FVIII titres of 6.7%. He responded to treatment with intravenous methylprednisolone and recombinant activated FVII. Screening for autoimmune diseases and malignancies was negative.

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Section: Discussionmentioning

confidence: 99%

“…Six cases of AHA following COVID-19 vaccination have occurred worldwide 7–10. Interestingly, most of them involved elderly patients with multiple comorbidities.…”

Section: Discussionmentioning

confidence: 99%

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Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine

et al. 2022

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“…Radwi et al [ 6 ] had recently reported the first case of AHA in a 69-year-old gentleman who presented with a bruising on wrist and muscular hematomas 9 days after receiving Pfizer mRNA COVID-19 vaccine. Another case of AHA developed in an elderly male patient with a background of autoimmune diseases (polymyalgia rheumatica) and hepatitis C virus, 8 days after receiving the first dose of the mRNA-1273 SARS-CoV-2 (Moderna) vaccine [ 5 ]. It is worth noting that AHA in a young female (as the case reported here) with no pregnancy and in the absence of comorbidities is even more rare.…”

Section: Discussionmentioning

confidence: 99%

“…This is the second case of AHA developing after receiving the Pfizer-BioNTech severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine. In addition, another case of AHA developed post mRNA-1273 SARS-CoV-2 vaccine manufactured by Moderna had been recently reported [ 5 ].…”

Section: Introductionmentioning

confidence: 99%