A case of acute acalculous cholecystitis complicated by primary Epstein-Barr virus infection

Suga, Kenichi; Shono, Miki; Goji, Aya; Matsuura, Sato; Inoue, Miki; Kawahito, Masami; Mori, Kazuhiro

doi:10.2152/jmi.61.426

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…Clinical evidence of AAC, however, is not common. There have been eighteen reported cases of pediatric patients with symptomatic EBV-associated AAC [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] although radiographic stigmata may be found in up to 25% of cases of pediatric acute EBV [18]. Surgical and antibacterial therapy have been proposed [6] but no reports of adverse outcome have been associated with expectant management alone.…”

Section: Discussionmentioning

confidence: 99%

“…It can have a wide range of manifestations, from asymptomatic to systemic, severe disease. Since first being reported in 2007 [1], there have been reports of 17 additional pediatric patients with acute acalculous cholecystitis (AAC) as a result of EBV infection [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. We present an additional case in which AAC was the clinically dominant manifestation of acute EBV mononucleosis.…”

Section: Introductionmentioning

confidence: 92%

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Acalculous Cholecystitis in a Seven-Year-Old Girl With Epstein-Barr Virus Infection

Rein¹,

Watkins²

2021

Cureus

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

Acalculous Cholecystitis in a Seven-Year-Old Girl With Epstein-Barr Virus Infection

Rein¹,

Watkins²

2021

Cureus

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“…Ultrasonografik görüntülemede safra kesesi duvar kalınlıkları 4,2-19 mm arası bildirilmiştir. Bu hastaların genel özellikleri Tablo I'de özetlenmiştir (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Hastamız da bu komplikasyonun nadir görüldüğü yaş grubundaydı.…”

Section: Discussionunclassified

A Rare Comlication of Ebstein-Barr Virus Infection: Acalculous Cholecystitis

Ocak¹,

Akçaboy²,

Çakmakçı³

et al. 2016

jpr

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GirişErken çocukluk döneminde Ebstein-Barr virüs (EBV) enfeksiyonu genellikle subklinik veya viral üst solunum yolu enfeksiyonunu taklit eden belirtilerle seyreder. Ancak geç çocukluk ve adölesan döneminde ateş, tonsillit ve lenf bezlerinde şişlikle karakterize enfeksiyöz mononükleoz klinik tablosuna yol açabilir. EBV kendi kendini sınırlayan bir enfeksiyon olmakla birlikte çok çeşitli komplikasyonlar bildirilmiştir. Hepatitle beraber hafif serum transaminaz yüksekliği sık görülen bulgu olsa da çocuklarda EBV ilişkili akut akalkülöz kolesistit (AAK) nadiren bildirilmiştir (1). Burada EBV enfeksiyonu sırasında gelişen ve seyrinde sorunsuz iyileşen bir akalkülöz kolesistit olgusu sunulmuştur. Olgu Sunumuİki yaşında erkek hasta iki gündür devam eden ateş, göz çevresinde ve karında şişlik şikayetleri ile başvurdu. Özgeçmiş ve soy geçmişinde özellik yoktu. Fizik incelemesinde genel ÖzABS TRACT Ebstein-Barr virüs (EBV) enfeksiyonu adölesan dönemde ateş, tonsillit, lenfadenit şeklinde seyreden enfeksiyöz mononükleoz tablosuna yol açsa da erken çocukluk döneminde enfeksiyon genellikle subklinik seyreder. EBV enfeksiyonu sırasında karaciğer enzim yüksekliği alışılmış bir bulgudur ancak akut akalkülöz kolesistit (AAK) nadir görülür. Burada akut EBV enfeksiyonu seyrinde gelişen AAK olgusu sunulmuştur. Hekimler EBV'ye bağlı gelişen enfeksiyoz mononükleoz seyri sırasında akut kolesistit gelişebileceğini, klinik iyileşmeye paralel olarak bu komplikasyonun düzeleceğini akılda bulundurmalıdır. Anahtar Kelimeler: Akut akalkülöz kolesistit, Ebstein-Bar virüs, çocuk Infection with Ebstein-Barr virüs (EBV) causes clinical signs such as fever, tonsillitis, lymphadenitis in adolescents, whereas it is mainly asymptomatic during early childhood. Elevations in liver function tests are known signs in EBV infection but acute acalculous cholecystitis (AAC) is rare. Herein, we report AAC in the course of acute EBV infection. Physicians should keep in mind that acute cholecystitis may develop during the course of EBV related infectious mononucleosis and this complication will recover-paralel to the clinical improvement of the primary disease.

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“…After identifying 671 articles, 153 articles involving 171 cases were eligible: 104 viral infection and 67 rheumatic disease AAC patients. [8,11–162] Viral infection types included: Epstein Barr virus, hepatitis virus, dengue virus, SARS-CoV-2 (COVID-19), human immunodeficiency virus, and cytomegalovirus. Rheumatic diseases included: systemic lupus erythematosus, adult-onset Still disease, Henoch-Schönlein purpura, polyarteritis nodosa, Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis), microscopic polyangiitis, temporal arteritis, Wegener granulomatosis (granulomatosis with polyangiitis), Kawasaki syndrome, systemic juvenile idiopathic arthritis, and juvenile dermatomyositis (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Is conservative management a safe approach for patients with acute acalculous cholecystitis presenting with an acute abdomen?

Chang,

Wang,

Shi

et al. 2023

Medicine

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Patients with acute acalculous cholecystitis (AAC) often present with acute abdominal symptoms. However, recent clinical studies have suggested that some patients with AAC and an acute abdomen, especially when caused by viruses or rheumatic disease, may not require cholecystectomy and that conservative treatment is adequate. Whether cholecystectomy is superior to conservative treatment for patients with AAC presenting with a severe acute abdomen is still uncertain. This was a case series study of AAC-related literature published between 1960 and 2022. In total, 171 cases (104 viral infection-associated AAC and 67 rheumatic disease-associated AAC) were included. The prognoses of patients receiving cholecystectomy or conservative treatment were compared. To account for confounding factors, etiological stratification and logistic regression were performed. The prognosis was similar for patients undergoing cholecystectomy and conservative treatment (P value .364), and virus infection-associated AAC had a better prognosis than rheumatic disease-associated AAC (P value .032). In patients with AAC caused by viruses or rheumatic disease, the acute abdomen can be adequately managed by conservative treatment of the underlying etiology and does not mandate surgical intervention.

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A case of acute acalculous cholecystitis complicated by primary Epstein-Barr virus infection

Cited by 14 publications

References 10 publications

Acalculous Cholecystitis in a Seven-Year-Old Girl With Epstein-Barr Virus Infection

Acalculous Cholecystitis in a Seven-Year-Old Girl With Epstein-Barr Virus Infection

A Rare Comlication of Ebstein-Barr Virus Infection: Acalculous Cholecystitis

Is conservative management a safe approach for patients with acute acalculous cholecystitis presenting with an acute abdomen?

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