A case of acute coronary syndrome following the use of parenteral penicillin: Kounis syndrome

Tok, Derya; Özcan, Fırat; Şentürk, Bihter; Gölbaşı, Zehra

doi:10.5543/tkda.2012.54077

Cited by 12 publications

(6 citation statements)

References 12 publications

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“…Syndrome may vary. In some patients lifethreatening allergic reactions such as anaphylaxis are on the forefront and might result with death; while in some patients symptoms such as chest pain are accompanied with mild allergic reactions (5). In our patient with Kounis syndrome was presented with angioedema, chest pain and feeling of discomfort.…”

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 63%

“…Adrenaline which is the main drug using for treatment of anaphylaxis should be administered to selected patients due to its effect of increased oxygen usage of heart and increased risk of vasospasm and dysrhythmias. To decrease vasospasm; calcium channel blockers and nitrates are recommended in Kounis Syndrome treatment (5,10). In our patient we administered aspirin and ticagrelor loading dosage for acute coronary syndrome; antihistaminics and steroid for allergic reaction.…”

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 93%

“…Aside from clinical presentation, high levels of serum histamine, triptase, spesific immunoglobulin E antibodies and eosinophils supports the diagnosis of Kounis Syndrome. Because of the low half-life of histamine (10 mins) and tryptase (90 mins) after onset of the reaction, their usage in diagnosis is limited (5). In our hospital's emergency department, these tests can not be performed, therefore our patient's serum levels are unknown.…”

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 99%

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Non-Steroidal Anti-Inflammatory Drug Induced Kounis Syndrome

Hocagil¹,

Hocagil²,

Ülker³

et al. 2018

MJWBS

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Kounis syndrome is a very rare syndrome which includes anaphylactic, anaphylactoid and hypersensitivity reactions accompanied with mast cell activation and acute coronary syndrome. In this case we aimed to define kounis syndrome. A 68 years old male patient applied to emergency department with back pain. After administration of the intramuscular analgesic; the patient suffered from symptoms such as dizziness, burning sensation all over the body. Patient was examined and blood pressure was 75/45 mmHg, heart rate was 90 beats/minute and respiratory rate was 14 /minute. The patient was detected with hyperemic skin and minimal uvular edema. Electrocardiography findings were ST segment elevations at derivations D2, D3, aVF, V5, V6 and ST segment depressions at derivations V1, V2, V3, D1, aVL. After percutaneous coronary angiography, coronary arteries were detected normal. The patient, newly diagnosed with acute coronary syndrome after allergen exposure, with positive skin findings and hypotension was evaluated as Kounis syndrome. There are 3 types of Kounis syndrome. These are defined as vasospastic allergic angina, allergic myocardial infarction and eosinophil and mast cell infiltration related stent thrombosis. The patient, without abnormal coronary arteries findings, was detected with coronary artery syndrome secondary to vasospasm. Increased exposure to allergens, increased awareness of physicians about Kounis syndrome, overconsumption of medicines contributes to increase this syndrome. The incidence of Kounis Syndrome has increasing but diagnosis of Kounis Syndrome is inadequate and easily overlooked. Most of all patients, presented with allergic reactions, should be evaluated for Kounis syndrome.

show abstract

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 63%

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 93%

Section: Clinical Presentation Of Patients With Kounismentioning

confidence: 99%

See 1 more Smart Citation

Non-Steroidal Anti-Inflammatory Drug Induced Kounis Syndrome

Hocagil¹,

Hocagil²,

Ülker³

et al. 2018

MJWBS

View full text Add to dashboard Cite

show abstract

“…Anaphylaxis is a form of life-threatening reaction of an acute urticaria or allergic reaction and is usually accompanied by severe skin, respiratory and cardiovascular system findings, as well as the only finding to diagnose an anaphylaxis is the hypotension that develops after exposure to allergen in clinical findings. 5 , 6 Allergic reactions following Hirudotherapy have already been reported. 7 A severe type-IV hypersensitivity reaction following pruritus, erythema, facial edema and nasal obstruction following hirudotherapy has been reported in literature.…”

Section: Discussionmentioning

confidence: 99%

Kounis syndrome due to hirudotherapy (leech therapy) in emergency department; a case report

Çakmak

Çalteki̇n

Gökçen

et al. 2018

Turkish Journal of Emergency Medicine

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Kounis Syndrome is the development of acute coronary syndrome (ACS) because of allergic reactions; allergens, such as foods, insect venom, iodine contrast agent or drugs can cause this syndrome. Hirudotherapy (leech therapy) is increasingly used as a useful therapeutic option in a variety of medical and surgical procedures, and potential complications related to this therapy include Aeromonas species infections, bleeding, anemia and allergic reactions. Here, we present a patient diagnosed as Type 1 Kounis Syndrome after using hirudotherapy for her knee aches. 41-year-old woman admitted to emergency department with sudden onset of face edema, shortness of breath and chest pain complaints and diagnosed as an allergic reaction and anaphylaxis due to leech therapy. Kounis Syndrome should be considered in acute coronary syndrome patients who were admitted to emergency department with anaphylaxis clinic.

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“…it is a hypersensitivity reaction which develops after allergen exposure. initially, it was defined as allergic angina by Nicholas kounis in 1991. several drugs (NsaiDs, antibiotics, antineoplastic agents) and toxins such as the ones after a bee sting may cause kounis syndrome (2). The basic pathophysiology of kounis syndrome is degranulation of the mast cell, located in the tunica intima layer of coronary artery and atherosclerotic plaques, and the release of inflammatory mediators after the contact with an allergen (3).…”

Section: Introductionmentioning

confidence: 99%