A case of acute epiglottitis caused by Haemophilus influenzae type a in an adult

Cerqueira, Ashley M.; Tsang, Raymond S. W.; Ulanova, Marina

doi:10.1099/jmmcr.0.001552

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…We found that serum bactericidal activity in First Nations adults extended beyond recognition of Hia strains currently circulating in the region, i.e. clonal type ST-23 [ 13 , 22 , 23 ]. Some isolates we tested have not been identified in the region since observations started in 2002, e.g.…”

Section: Discussionmentioning

confidence: 99%

Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study

et al. 2018

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During the last two decades, Haemophilus influenzae serotype a (Hia) emerged as an important cause of invasive disease in Canadian First Nations and Inuit, and Alaskan Native populations, with the highest rates reported in young children. Immunocompetent adults, in contrast to children, do not typically develop invasive Hia disease. To clarify factors responsible for an increased burden of invasive Hia disease in certain population groups we studied serum bactericidal activity (SBA) against Hia and quantified IgG and IgM specific to Hia capsular polysaccharide in healthy adult members of two First Nations communities: 1) with reported cases of invasive Hia disease (Northern Ontario, NO), and 2) without reported cases (Southern Ontario, SO), in comparison to non-First Nations living in proximity to the NO First Nations community, and non-First Nations elderly non-frail Canadians from across the country (total of 110 First Nations and 76 non-First Nations). To elucidate the specificity of bactericidal antibodies, sera were absorbed with various Hia antigens. Naturally acquired SBA against Hia was detected at higher rates in First Nations (NO, 80%; SO, 96%) than non-First Nations elderly Canadians (64%); the SBA titres in First Nations were higher than in non-First Nations elderly Canadians (P<0.001) and NO non-First Nations adults (P>0.05). Among First Nations, SBA was mediated predominantly by IgM, and by both antibodies specific to Hia capsular polysaccharide and lipooligosaccharide. Conclusions: The SBA against Hia is frequently present in sera of First Nations adults regardless of the burden of Hia disease observed in their community; it may represent part of the natural antibody repertoire, which is potentially formed in this population under the influence of certain epigenetic factors. Although the nature of these antibodies deserves further studies to understand their origin, the data suggest that they may represent important protective mechanism against invasive Hia disease.

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Section: Discussionmentioning

confidence: 99%

Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study

et al. 2018

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“…11 To our knowledge, only two cases of adult Hia-associated epiglottitis have been reported. 4,12 This is the first reported in a child.…”

Section: Discussionmentioning

confidence: 89%

Non‐vaccine Haemophilus influenzae type a epiglottitis

Almuzam

Lin

Wong

et al. 2020

J Paediatrics Child Health

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“…In addition, most cases of invasive Hia infections manifest between 6 months and 2 years after birth [13]. Hence, it is very rare for this infection to be observed in an elderly individual above the age of 65 [4,14].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, arthritis due to invasive Hia occurs mostly in infants, and most of them have no underlying disease [4,9e12]. Elderly patients with Hia usually have underlying conditions such as respiratory diseases (including pulmonary tuberculosis and chronic obstructive pulmonary disease) [4,10] and obesity/diabetes [14]. There are no reports on patients with other immunosuppressed conditions, including those with decreased splenic function.…”

Section: Discussionmentioning

confidence: 99%

Invasive Haemophilus influenzae type a infection and polyarthritis in a 72-year-old Japanese man: A case report

Kenzaka

Goda

Kubota

et al. 2021

Journal of Infection and Chemotherapy

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Haemophilus influenzae is a small, nonmotile, non-spore-forming bacterium classified into 6 serotypes (a to f) and non-typeable strains that lack a capsule. Although H. influenzae serotype a (Hia) is prevalent in Canada, the United States, Brazil, Australia, across the African continent, and several other locations, it has not been reported in Japan thus far. Our case was of a 72-year-old Japanese man who sought medical consultation after presenting with chills, fever, and polyarthritis. Cultures of blood and synovial fluid from the left knee revealed H. influenzae infection. Diagnostic imaging showed poor contrast regions in both kidneys, fluid retention around both knee joints, the left shoulder joint, and both elbow joints. Subsequently, the patient was diagnosed with invasive H. influenzae infection accompanied by polyarthritis and renal infarction. 16S ribosomal RNA gene sequencing revealed that the bacterial strain was Hia. The patient was treated with antimicrobial agents and arthroscopic curettage. We present a case of invasive Hia infection accompanied by polyarthritis and renal infarction. To the best of our knowledge, this is the first case of Hia infection in Japan. The case is very rare considering that the disease occurred in an elderly patient who developed polyarthritis.

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A case of acute epiglottitis caused by Haemophilus influenzae type a in an adult

Cited by 8 publications

References 40 publications

Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study

Characterization of natural bactericidal antibody against Haemophilus influenzae type a in Canadian First Nations: A Canadian Immunization Research Network (CIRN) Clinical Trials Network (CTN) study

Non‐vaccine Haemophilus influenzae type a epiglottitis

Invasive Haemophilus influenzae type a infection and polyarthritis in a 72-year-old Japanese man: A case report

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