A Case of Acute Hepatitis due to Brucellosis

Sunmez, Sule; Çağatay, Atahan; Karadeniz, Aslı; Özsüt, Halit; Eraksoy, Haluk; Çalangu, Semra

doi:10.1097/01.smj.0000220845.13081.a0

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…Brucellosis is a systemic disease which can involve any organ [13,16,[19][20][21][22][23][24]. We present this case to emphasize a rare clinical variation of brucellosis, specifically the development of acute renal failure.…”

Section: Discussionmentioning

confidence: 95%

“…It can affect people in every age group. There are many clinical studies about multiorgan involvement of the disease [10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Currently, most patients are misdiagnosed with arthritis or other non-specific infections which are important to consider in a differential diagnosis [8,9,11,13,16,21].…”

Section: Introductionmentioning

confidence: 99%

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Acute renal failure due to Brucella melitensis

Dagli

Dokur

Guzeldag

et al. 2011

J Infect Dev Ctries

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We present the case of a 42-year-old male patient who applied to the emergency department of our hospital with clinical nephritis, orchitis, acute renal failure without endocarditis, and a low-grade fever. Brucella agglutinin titers were 1:160, Rose Bengal test was positive and Brucella melitensis was isolated from urine and blood cultures.. A combination of oral rifampin (600 mg/day) and doxycycline (200 mg/day) was administered along with supportive treatment leading to resolution of his clinical status by eight weeks. This was a rare complication of severe renal involvement due to brucellosis which resolved with antibiotic treatment.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Acute renal failure due to Brucella melitensis

Dagli

Dokur

Guzeldag

et al. 2011

J Infect Dev Ctries

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“…In one prospective study from Iran including 111 children with brucellosis, fever (73.9%), sweating (67.6%), arthralgia (49.5%) and splenomegaly (18%) were common findings 24 . Hepatic involvement in brucellosis is not rare; liver function tests are usually mildly elevated and hepatomegaly may be documented in 15–20% of cases 25 . We found that 20% of patients had asymptomatic rise in liver function tests and 15.6% of patients had hepatomegaly.…”

Section: Discussionmentioning

confidence: 99%

Presentation, complications, and treatment outcome of brucellosis in Turkish children

Tanır

Tufekci

Tuygun

2009

Pediatrics International

101

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“…Hepatic involvement in brucellosis is not rare and hepatomegaly may be documented in 15–20% of cases [3]. However, liver function tests are usually mildly elevated [1,3].…”

Section: Discussionmentioning

confidence: 99%

“…However, liver function tests are usually mildly elevated [1,3]. The spectrum of pathological findings in brucella hepatitis is varied.…”

Section: Discussionmentioning

confidence: 99%

An unusual presentation of brucellosis, involving multiple organ systems, with low agglutinating titers: a case report

et al. 2007

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BackgroundBrucellosis is a multi-system disease that may present with a broad spectrum of clinical manifestations. While hepatic involvement in brucellosis is not rare, it may rarely involve the kidney or display with cardiac manifestations. Central nervous system involvement in brucellosis sometimes can cause demyelinating syndromes. Here we present a case of brucella hepatitis, myocarditis, acute disseminated encephalomyelitis, and renal failure.Case presentationA 26-year-old man presented with fever, ataxia, and dysarthria. He was a shepherd and gave a history of low grade fever, chilly sensation, cold sweating, loss of appetite, arthralgia and 10 Kg weight loss during the previous 3 months. He had a body temperature of 39°C at the time of admission. On laboratory tests he had elevated level of liver enzymes, blood urea nitrogen, Creatinine, Creatine phosphokinase (MB), and moderate proteinuria. He also had abnormal echocardiography and brain MRI. Enzyme-linked immunosorbent assay for IgG and IgM was negative. Standard tube agglutination test (STAT) and 2-mercaptoethanol (2-ME) titers were 1:80 and 1:40 respectively. Finally he was diagnosed with brucellosis by positive blood culture and the polymerase chain reaction for Brucella mellitensis.ConclusionIn endemic areas clinicians should consider brucellosis in any unusual presentation involving multiple organ systems, even if serology is inconclusive. In endemic areas low STAT and 2-ME titers should be considered as an indication of brucellosis and in these cases additional testing is recommended to rule out brucellosis.

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A Case of Acute Hepatitis due to Brucellosis

Cited by 6 publications

References 2 publications

Acute renal failure due to Brucella melitensis

Acute renal failure due to Brucella melitensis

Presentation, complications, and treatment outcome of brucellosis in Turkish children

An unusual presentation of brucellosis, involving multiple organ systems, with low agglutinating titers: a case report

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