A Case of Acute Myocardial Infarction Associated with Topical Use of Minoxidil (RiUP) for Treatment of Baldness.

Abstract

SUMMARYA 45-year-old Japanese man with paroxysmal atrial fibrillation (AF) developed acute anteroseptal myocardial infarction (MI). He had used 1 % topical minoxidil (RiUP ® ) once a day for 4 months before the onset of MI for treatment of baldness. Coronary angiography demonstrated severe stenosis at the proximal portion of the left anterior descending coronary artery with a filling defect. Electrocardiographic monitoring revealed paroxysmal AF and sinus bradycardia with sinus arrests, suggestive of sick sinus syndrome. Topical minoxidil is now widely used for the treatment of male pattern baldness. Although it may be difficult to relate topical use of minoxidil to myocardial ischemia, a greater awareness of its toxicity will be necessary, and patients with cardiovascular disorders should be excluded from the therapy. (Jpn Heart J 2000; 41: 519-523)

Topical Use of Minoxidil in Children and Systemic Side Effects

“…The case of a man with paroxysmal atrial fibrillation and sinus arrhythmia, who experienced acute MI after 4 months of therapy with topical minoxidil solution 1% for treating baldness was reported recently [4] .…”

Sinus Node Dysfunction in a Child After Developed by the Use of Topical Minoxidil

“…Its topical use has further systemic side-effects upon its absorption (6). Although only one sinus arrest in an adult patient was reported due to the use of minoxidil, this patient had coronary artery disease, which may cause sinus node dysfunction, and the patient had myocardial infarction (7). To date, no symptomatic sinus arrest due to the use of minoxidil among the pediatric cases has been reported.…”

Interconnected PolymerS TeChnology (IPSTiC): An Effective Approach for the Modulation of 5α-Reductase Activity in Hair Loss Conditions

“…The second one is a 5α-reductase inhibitor able to prevent testosterone conversion into DHT [ 11 ]. However, these two therapeutic agents cause several adverse effects such as local irritation, bloating, erythema, tachycardia, myocardial infarction in the case of minoxidil and abnormal sexual function, confusion, cold sweats, faintness, dizziness, severe myopathy [ 1 , 12 , 13 , 14 , 15 ].…”