A case of adrenocortical carcinoma accompanying secondary acute adrenal hypofunction postoperation

Kou, Kaichang; Zhang, Haiwen; Zhang, Conggui; Xie, En-Bo; Chen, Yuguo; Wang, Guangyi; Lv, Guoyue

doi:10.1186/s12957-018-1326-5

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Taken together, these data indicate that the substances described in the leaves of N. procerum proved to be efficient in modulating significant responses mediated by macrophages. This can be a potential alternative as a therapeutic agent applied www.nature.com/scientificreports www.nature.com/scientificreports/ were also carried out to evaluate the cytotoxic activity of in vitro cultured N. procerum Lindm against H295R cell line, a carcinoma with rare, heterogeneous malignancy and a very poor prognosis 76 .…”

Section: Chlorophyll Quantification Leaves Ofmentioning

confidence: 99%

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Gollo

Tanobe

Pereira

et al. 2020

Sci Rep

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In this study, Response surface methodology (RSM) was applied to optimize the yield of crude methanolic extract of Mitragyna speciosa leaves using Ultrasound-assisted extraction (UAE). The crude methanolic extract and its fractions were quanti ed in terms of total phenolic content and total avonoid content, along with characterized using Fourier-transform infrared and Gas chromatography-mass spectrometry. The results showed the maximum yield of 49.72% at the optimal conditions (temperature, 34 °C; time, 25 min; and volume of solvent, 166 mL). The recovery crude methanolic extract for TPC and TFC were 137.3 ± 15.7 mg GAE/g and 90.3 ± 15.3 mg RE/g, respectively.

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Section: Chlorophyll Quantification Leaves Ofmentioning

confidence: 99%

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Gollo

Tanobe

Pereira

et al. 2020

Sci Rep

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“…As far as we know, adrenal hypofunction is a very rare phenomenon after TACE, as it has not been reported so far. Adrenal hypofunction often occurs after adrenal gland removal, and related studies have shown that over 23% of patients with adrenal tumor resection have acute adrenal hypofunction[ 7 , 14 , 15 ]. Although adrenal cortical cancer is divided into functional and nonfunctional, both types of ACC may cause acute adrenal hypofunction.…”

Section: Discussionmentioning

confidence: 99%

Rare complication of acute adrenocortical dysfunction in adrenocortical carcinoma after transcatheter arterial chemoembolization: A case report

Wang

Sun

Zhang

et al. 2021

WJCC

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BACKGROUND Adrenocortical carcinoma (ACC) is a rare and highly invasive endocrine malignant tumor with a poor prognosis. Although surgical resection is the main treatment for ACC, postoperative recurrence and metastasis have become the important factors of death. Transcatheter arterial chemoembolization (TACE) is an important option for the treatment of advanced ACC with liver metastasis. However, due to the small number of patients treated for ACC, the safety of the operation is not completely clear and needs to be further studied. CASE SUMMARY A 47-year-old patient with ACC after surgery was admitted for reexamination by abdominal computerized tomography suggesting liver metastasis. Because the patient expressed reluctance to undergo surgery again, we treated her with TACE for the liver lesions. After treatment, symptoms of acute adrenal dysfunction such as decreased blood pressure, anorexia, and fatigue appeared, which were relieved after hydrocortisone treatment. To date, the patient's liver lesion is well controlled and no other metastases are observed. CONCLUSION We report a rare case of acute adrenal hypofunction after TACE. Glucocorticoid supplementation can alleviate the symptoms.

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“…Adrenal hypofunction often occurs after adrenal gland removal or long-term use of glucocorticoids, etc [12][13]. As far as we know, adrenal hypofunction is a very rare phenomenon after arterial duct embolization, and it has not been reported so far.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Stage IV Adrenocortical Carcinoma with Acute Adrenocortical Dysfunction After Trans-Catheter Arterial Chemo-Embolization (TACE)

Wang

Sun

Zhang

et al. 2020

Preprint

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Background: Adrenocortical carcinoma(ACC) is a rare and highly invasive endocrine malignant tumor with poor prognosis and insensitivity tochemotherapy, which don't have effective treatment. Although Surgical resection is considered to be the main treatment for ACC, postoperative recurrence and metastasis have become the most important factors of death. Therefore, local treatments such as trans-catheter arterial chemo-embolization, radiofrequency ablation become be new treatment for ACC. Trans-catheter arterial chemo-embolization therapy for ACC patients with liver metastasis has good efficacy and can effectively reduce the tumor burden of patients, which is considered to be safe and easy for patients. Case presentation: We report a 47-year-old female patient diagnosed with stage Ⅳ ACC with liver metastases, who developed symptoms of acute adrenocortical dysfunctions after hepatic arterial catheter chemo-embolization.Conclusion: Trans-catheter arterial chemo-embolization therapy for ACC patients with liver metastasis is not completely safe, and there is a certain probability that it will lead to secondary adrenal dysfunction. Hydrocortisone supplementation can effectively alleviate the symptoms.

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A case of adrenocortical carcinoma accompanying secondary acute adrenal hypofunction postoperation

Cited by 5 publications

References 16 publications

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Phytochemical analysis and biological activities of in vitro cultured Nidularium procerum, a bromeliad vulnerable to extinction

Rare complication of acute adrenocortical dysfunction in adrenocortical carcinoma after transcatheter arterial chemoembolization: A case report

A Rare Case of Stage IV Adrenocortical Carcinoma with Acute Adrenocortical Dysfunction After Trans-Catheter Arterial Chemo-Embolization (TACE)

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