A Case of Amiodarone-Associated Pulmonary Toxicity

Abstract

Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia. There are numerous side effects associated with amiodarone therapy, including corneal microdeposits. Skin reactions and others. Pulmonary toxicity, however, represents the most serious adverse reaction limiting the clinical efficacy of this antidysrhythmic drug, Recently, we experienced a case of amiodarone-induced pulmonary toxicity confirmed by open lung biopsy with light-and electron-microscopy. So, we report a case of amiodarone-induced pulmonary toxicity with a literature review.

The incidence and predictors of overall adverse effects caused by low dose amiodarone in real-world clinical practice

“…Many studies have investigated the adverse effects of amiodarone; however, most were performed decades ago using a small sample size. Most of these studies were case reports or case series and focused on the toxicity of amiodarone toward specific organ systems [ 3 , 4 , 5 , 6 ]. In addition, the overall adverse events associated with amiodarone were not assessed in those studies.…”