A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage

Kim, Ju Seung; Jang, Young Woo; Lee, Ji Won; Kim, Jin Yong; Jung, Young Kul; Chung, Dong Hae; Kwon, Oh Sang; Kim, Yun Soo; Choi, Duck Joo

doi:10.3350/kjhep.2011.17.3.229

Cited by 14 publications

(9 citation statements)

References 14 publications

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“…Improper protein and carbohydrate metabolism could alter the level of transaminase activities. Kim et al. (2011) reported that amoxicillin affects the liver and could activate the enzyme.…”

Section: Discussionmentioning

confidence: 99%

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

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Labeo rohita were exposed to amoxicillin at a concentration of 1 mg/L (Treatment -I) and 0.5 mg/L (Treatment-II) for a period of 35 days. Numerous alterations were found in amoxicillin treatment groups when compared to the control group. Hemoglobin (Hb), hematocrit (Hct), and erythrocytes (RBCs) levels were significantly ( P < 0.05) decreased. Leukocytes (WBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were significantly ( P < 0.05) increased. In the plasma and gill tissues, ionic compounds (sodium, potassium, and chloride) levels were significantly declined throughout the treatment period. The plasma biochemical profiles were significantly altered: glucose level remained low (except at the end of 7 th day in Treatment -I) till 35 days of the treatment period. Biphasic trend occurred in the protein level, significant increase was observed on 7 th and 28 th day (Treatment -I and -II), and 35 th day (Treatment -I), and in remaining days its level was found to be decreased. Glutamate oxaloacetate transaminase (GOT) activity in the plasma was inhibited significantly, whereas in the gill, liver, and kidney tissues the enzyme activity was elevated. Plasma glutamate pyruvate transaminase (GPT) activity was inhibited throughout the study period. GPT activity in the gill was found to be elevated during the treatment period. Liver GPT activity was elevated in all the treatments except 28 th (Treatment-I) and 35 th day (Treatment-I, and II). GPT activity in the kidney was elevated (except 14 th day in Treatment-II). Lactate dehydrogenase (LDH) activity was inhibited in plasma (except 14 th day in Treatment-II), gill, liver (except 7 th day in Treatment-I), and kidney tissues significantly ( P < 0.05). The present study emphasizes that amoxicillin at 1 and 0.5 mg/L concentrations affects the hematological/biochemical/electrolytes/enzymological parameters of fish and these biomarkers serve as an effective test system for environmental risk assessment of pharmaceuticals in the aquatic environment.

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“…Improper protein and carbohydrate metabolism could alter the level of transaminase activities. Kim et al. (2011) reported that amoxicillin affects the liver and could activate the enzyme.…”

Section: Discussionmentioning

confidence: 99%

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Umamaheswari

Renuka

Ramesh

et al. 2019

Heliyon

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“…There were very rare case reports discussing amoxicillin‐induced liver injury, which were always characterized by a short latency period, eosinophilia, skin rash, and arthralgias. Histological examination of amoxicillin‐induced liver injury showed cholestasis, hepatocellular inflammation, and bile duct damage and loss . There were no clinical manifestations and no evidence of duct damage in our case.…”

Section: Discussionmentioning

confidence: 53%

Phenobarbital‐Induced Liver Injury With Nodal Angiomatosis

Cheng

Yeh

2019

Hepatology

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“…Cholestasis mainly involves portal and periportal areas [ 4 - 5 ]. Ductopenia, necrosis and degeneration of ductal epithelial cells, and vacuolization and necrosis of liver cells are some other findings besides the granulomatous inflammatory process [ 5 , 13 - 15 ].…”

Section: Discussionmentioning

confidence: 99%

Delayed Presentation of Drug-Induced Hepatic Injury

Ahmed¹,

Onteddu²,

Jabur³

et al. 2020

Cureus

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Drug-induced hepatotoxicity is a major cause of acute liver failure (ALF) in the United States. There are many offending agents like prescription drugs and herbal remedies. However, the most common prescription medication involved worldwide is amoxicillin-clavulanate. We report an unusually delayed presentation of severe cholestatic hepatitis caused by amoxicillinclavulanate in a 20-year-old female with worsening hyperbilirubinemia that was successfully treated with corticosteroids and ursodeoxycholic acid (UDCA).

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A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage

Cited by 14 publications

References 14 publications

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Chronic amoxicillin exposure affects Labeo rohita: assessment of hematological, ionic compounds, biochemical, and enzymological activities

Phenobarbital‐Induced Liver Injury With Nodal Angiomatosis

Delayed Presentation of Drug-Induced Hepatic Injury

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