A Case of Amyloid Goiter Secondary to Crohn's Disease.

Habu, Satoshi; Watanobe, Hajime; Kimura, Ken‐ichi; Suda, Toshio

doi:10.1507/endocrj.46.179

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…Amyloidosis is characterized by the deposition of fibrillary proteins that can accumulate in various organs [ 49 ] and is classified as primary or secondary. Secondary amyloidosis is a well-known complication of CD, as demonstrated by previous studies, and has an incidence of 0.5%–9.0% [ 42 , 48 ]. However, the prevalence of amyloidosis is less in UC patients.…”

Section: Ag In Ibdmentioning

confidence: 99%

Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review

Shizuma

2016

BioMed Research International

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The aim of this report was to review and summarize the literature on cases of concomitant inflammatory bowel disease (IBD) and thyroid diseases. We included the following previous case reports of concomitant IBD and thyroid diseases: 16 cases of ulcerative colitis (UC) and Graves' disease (GD), 3 cases of Crohn's disease (CD) and GD, 10 cases of CD and Hashimoto's thyroiditis (HT), 4 cases of IBD and subacute thyroiditis (SAT) or SAT-like symptoms, and 13 cases of IBD (12/13 cases were CD) and amyloid goiter. There might be no obvious differences of prevalence of thyroid dysfunction (hyper- or hypothyroidism), GD, and thyroid cancer between IBD patients and general populations. However, concomitant UC and HT might be relatively common in patients with multiple autoimmune disorders, and AG is one of the complications with CD patients. There might be no obvious differences of fatal prognoses between IBD patients with thyroid diseases and patients with thyroid diseases without IBD.

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Section: Ag In Ibdmentioning

confidence: 99%

Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review

Shizuma

2016

BioMed Research International

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“…In primary amyloidosis, amount of monoclonal plasma cells increase in bone marrow, similarly immunoglobulin light chains (AL type) increase in the affected tissue. Secondary amyloidosis accompanies malignancies or chronic inflammatory diseases such as tuberculosis, rheumatoid arthritis, ankylosing spondylitis, cystic fibrosis, bronchiectasis and inflammatory bowl disease 6 . Approximately, 75% of patients with secondary amyloidosis that accompanying to CD are male, just as our case 14–16 .…”

Section: Discussionmentioning

confidence: 59%

“…The association of CD with amyloidosis is a rare entity that first time reported by Moschkowitz in 1936 14,15,21 . Afterwards, Olson et al reported a case of secondary amyloidosis related to CD, in 1948 6 . Since then, some similar cases and reviews reported by various authors, between 1982 and 2009 22,23 .…”

Section: Discussionmentioning

confidence: 87%

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Amyloid goiter related with Crohn's disease: A rare association

Özemir

Bilgiç

Bayraktar

et al. 2014

International Journal of Surgery Case Reports

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INTRODUCTIONAmyloid goiter (AG) is characterized by enlargement of the thyroid gland as a result of extensive amyloid deposition in a bilateral and diffuse manner.PRESENTATION OF CASEA 58-year-old male patient was diagnosed of Crohn's Disease (CD). He was admitted to our clinic with complaint of respiratory distress and rapid growth swelling in the neck. Ultrasound examination revealed huge multinodular goiter on both sides of thyroid gland. We performed bilateral total thyroidectomy. Pathological evaluation revealed AG.DISCUSSIONAmyloid leads to degeneration in tissues, thereby disrupts the function of the relevant organs. It is important to distinguish AG from other reasons of goiter, particularly thyroid medullary cancer that can cause amyloid deposition in thyroid gland. Secondary amyloidosis frequently involves thyroid gland at microscopic level, but rarely causes goiter. An analysis of current literature revealed that only few cases of AG occurred secondary to CD. Herein we presented a case of AG who has rapidly growing goiter that associated with CD.CONCLUSIONAG must be kept in mind in case of rapidly growing goiter, especially in patients with chronic inflammatory bowel diseases.

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“…Deposition of amyloid in the thyroid gland may occur in a number of different disease conditions. It occurs in about 50% to 70% of medullary thyroid carcinoma, secondary to long standing inflammatory conditions such as rheumatoid arthritis [2], cystic fibrosis [3] [4], ankylosing sponilitis [5] and Crohn's disease [6]. AG may also be secondary to long standing chronic infectious inflammatory diseases such as bronchiectasis [7] and tuberculosis [8].…”

Section: Introductionmentioning

confidence: 99%

Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature

Mohammed¹,

Yassin²,

Radwan³

et al. 2015

OJPathology

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Amyloid goiter (AG) is a rare but well-established disease entity that may occur in a number of conditions. In the following article, we will report two cases of AG. Both patients were young males: 28 & 24 years old, presented with rapidly enlarging thyroid gland manifested with pressure effects (dyspnea and hoarseness of voice). Provisional clinical diagnosis was malignant thyroid neoplasm. One of the patients was markedly hypothyroid while the other was euthyroid. Histopathological evaluation revealed extracellular deposition of deep pink homogenous material that was confirmed as amyloid with congo red. Patient in case 1 was primary localized AG while patient in case 2 was systemic amyloidosis secondary to interstitial pulmonary fibrosis (IPF) that was first manifested by AG. The main aims of the article were to describe histopathological features of amyloidosis of the thyroid gland and to raise awareness of AG to be included in the differential diagnosis in patients presented with rapidly enlarging goiter with mass effects.

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A Case of Amyloid Goiter Secondary to Crohn's Disease.

Abstract: Abstract.We herewith report a case of amyloid goiter secondary to Crohn's disease.

Cited by 13 publications

References 10 publications

Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review

Concomitant Thyroid Disorders and Inflammatory Bowel Disease: A Literature Review

Amyloid goiter related with Crohn's disease: A rare association

Amyloid Goiter: Clinicopathological Assessment of Two Cases and Review of Literature

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