A case of an insect bite-like reaction in a patient with angioimmunoblastic T-cell lymphoma

Murao, Kazutoshi; Sogawa, Maiko; Kubo, Yoshiaki

doi:10.1684/ejd.2019.3571

Cited by 2 publications

(1 citation statement)

References 5 publications

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“… 15 , 16 , 17 , 18 It has also been reported that such patients can develop other types of lymphoma mostly with EBV infection. 19 , 20 , 21 However, our case is not ALK+ systemic ALCL involving the skin, or EBV‐associated LPD, rather pC‐ALCL following an insect bite.…”

Section: Discussionmentioning

confidence: 78%

Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites

Zhang

Chen

et al. 2021

J Cutan Pathol

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Primary cutaneous anaplastic large-cell lymphoma (pC-ALCL) is distinguished from systemic anaplastic large-cell lymphoma (S-ALCL) with cutaneous involvement.Although pC-ALCL is a unique entity with different genetics, clinical characteristics, and prognosis, its causes are unknown. Herein, we report the case of a Chinese woman with a 4-month history of a gradually enlarged ulcerative mass in her right forearm following an unidentified insect bite. Biopsy revealed an extensive infiltrate with patches of large anaplastic lymphoid cells. These cells were immunohistochemically positive for CD45, CD30, and TIA-1 and negative for CD2, CD3, CD4, CD5, CD20, CD7, CD8, and ALK-1. DUSP22-IRF4 rearrangement was detected; on the other hand, TP63 rearrangement was not observed by fluorescence in situ hybridization (FISH). No Epstein-Barr virus-encoded small RNAs (EBERs) were detected by ISH. Rearrangement of monoclonal TCR gene was found using BIOMED-2 polymerase chain reaction. No abnormality was found on the subsequent positron emission tomography-computed tomography (PET-CT) scan. After five cycles of cyclophosphamide + doxorubicin + vincristine + prednisolone (CHOP) chemotherapy, the patient achieved complete remission. This is the first report of a unique pC-ALCL with DUSP22-IRF4 rearrangement following an insect bite other than S-ALCL involving the skin.

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Section: Discussionmentioning

confidence: 78%

Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites

Zhang

Chen

et al. 2021

J Cutan Pathol

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A systematic review of the management of eosinophilic dermatosis of hematological malignancy

Tan,

Choong,

Tan

2024

Int J Dermatology

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Eosinophilic dermatosis of hematologic malignancy (EDHM) is a cutaneous manifestation seen in patients with hematoproliferative and lymphoproliferative disorders, most commonly chronic lymphocytic leukemia. This systematic review aimed to summarize the therapeutic interventions of EDHM. A comprehensive search yielded 71 studies, predominantly case reports and series. The most frequently reported modalities were systemic and topical corticosteroids, as well as treatment of the underlying malignancy. Responses to these treatments varied. Targeted therapies, including dupilumab and omalizumab, showed promise, as did other modalities such as montelukast, dapsone, doxycycline, and phototherapy. Higher‐quality studies should be conducted to facilitate higher‐quality management recommendations for EDHM.

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A case of an insect bite-like reaction in a patient with angioimmunoblastic T-cell lymphoma

Cited by 2 publications

References 5 publications

Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites

Primary cutaneous anaplastic large‐cell lymphoma with DUSP22‐IRF4 rearrangement following insect bites

A systematic review of the management of eosinophilic dermatosis of hematological malignancy

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