A Case of Anaphylaxis to Oral Minocycline

Jang, Jyongsik; Bae, Yun-Jeong; Kim, Yong Giun; Jin, Young–Joo; Park, Kyung Sun; Cho, You Sook; Moon, Hee‐Bom; Kim, Tae‐Bum

doi:10.3346/jkms.2010.25.8.1231

Cited by 20 publications

(19 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Allergy to minocycline has been reported in the medical literature (Jang et al . , Travassos et al . ).…”

Section: Discussionmentioning

confidence: 92%

“…One component of the triple antibiotic paste is minocycline, which belongs to the tetracycline family. Allergy to minocycline has been reported in the medical literature (Jang et al 2010, Travassos et al 2012). Hence, the use of such antibiotic pastes without verification of the patient's sensitivity to antibiotics might cause serious adverse reactions, especially due to its tetracycline component.…”

Section: Discussionmentioning

confidence: 96%

“…Although drugs of the tetracycline group are known for their potential to cause adverse reactions as well as allergies (Steinbruegge & Judson , Jang et al . , Miller et al . , Lebrun‐Vignes et al .…”

Section: Introductionmentioning

confidence: 99%

“…Although drugs of the tetracycline group are known for their potential to cause adverse reactions as well as allergies (Steinbruegge & Judson 1980, Jang et al 2010, Miller et al 2011, Lebrun-Vignes et al 2012, Travassos et al 2012, only one recent letter to the Editor of a dental journal has reported an allergy to Ledermix paste due to demeclocycline, one of the Ledermix paste components that belongs to the tetracycline family (Jetty & Sidebottom 2013).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Allergic reaction to the tetracycline component of Ledermix paste: a case report

et al. 2014

View full text Add to dashboard Cite

A 33-year-old female patient undergoing root canal retreatment of her right mandibular second premolar tooth experienced symptoms of type 1 allergy following the placement of an intracanal medicament containing a mixture of Ledermix paste and calcium hydroxide [Ca(OH)2 ]. Signs of the type 1 allergy included urticaria, pruritus all over the body, general malaise and fever. These all subsided after removing and flushing out the Ledermix paste-Ca(OH)2 mixture and redressing the root canal with Ca(OH)2 alone. Allergic scratch tests were performed, and these confirmed that the patient was allergic to tetracycline, one of the components of Ledermix paste.

show abstract

“…Allergy to minocycline has been reported in the medical literature (Jang et al . , Travassos et al . ).…”

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Allergic reaction to the tetracycline component of Ledermix paste: a case report

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Apesar da atividade satisfatória mostrada pela OTC, também é importante ressaltar que o material em desenvolvimento no presente estudo não deverá ser indicado em pacientes com hipersensibilidade às tetraciclinas (ou ao polímero), mesmo sendo este um material de uso tópico. A literatura mostra relatos de reações de hipersensibilidade às tetraciclinas (principalmente à minociclina) de severidade variada (Lebrun-Vignes et al, 2012), quando administradas por vias tópicas como a intracanal (Kaufman et al, 2014), dérmica e oftálmica (Rudzki;Rebandel, 1997), e sistêmicas como a via oral (Ogita et al, 2011;Jang et al, 2010;Lan et al, 2016 O efeito da nanofibra de PCL/OTC sobre o reparo do alvéolo dental foi avaliado, nesta pesquisa, através da análise histológica em modelo experimental em molares de ratos. Por apresentar marcadas diferenças em relação ao alvéolo dentário humano (Merzel;Salmon, 2008), o incisivo não foi escolhido para este estudo in vivo.…”

Section: Identificação De Osteoclastosunclassified

Nanofibras poliméricas carregadas com oxitetraciclina para tratamento de alveolite seca: estudo em ratos

Viera¹

View full text Add to dashboard Cite

Dry socket is one of the most common and symptomatic postoperative complications in tooth extraction, however, to date, it does not have an established treatment protocol. Oxytetracycline (OTC) is a broad-spectrum antibiotic, employed in the treatment of multiple infections. Nevertheless, in the last few years, first-generation tetracyclines such as OTC, have been avoided due to the development of resistant microorganisms. Fortunately, in recent years there has been a contrary trend thanks to control measures in the use of antibiotics. Controlled release systems can prevent the development of bacterial resistance and decrease the risk of adverse effects. This study aimed to prepare a polymeric nanofiber of polycaprolactone and oxytetracycline (PCL/OTC), and to evaluate its physical and biological properties in vitro and in vivo, aiming its use in the treatment of dry socket at the future. The OTC-charged polymeric nanofibers were prepared by electrospinning, and characterized by scanning electron microscopy (SEM) and drug release profile evaluation. The antibacterial activity of the nanofiber over a mixed biofilm containing Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Eikenella corrodens, Streptococcus sanguis, and Aggregatibacter actinomycetemcomitans was analyzed by counting the viable colony-forming units after 1, 4, 24, 30 and 48 h of contact. The alveolar repair process induced by the PCL/OTC nanofiber was evaluated histomorphologically and histomorphometrically after the treatment of dry socket in rat molars, and compared to the treatment with plain PCL nanofibers and Alvogyl TM , 7, 14 and 21 days after extraction. Finally, the identification and counting of osteoclasts were performed through the tartrate resistant acid phosphatase (TRAP) staining, at the same evaluation time points. PCL/OTC nanofibers presented random orientation in layers and multiform morphology. The release profile of the PCL/OTC system showed a burst effect within the first 8 hours, followed by a prolonged slow release period. The PCL/OTC nanofiber at a concentration of 132 μg OTC/mL reduced more than 50% of the biofilm colonies in the first few hours of release, followed by a maintenance period in which the percentage of bacterial colonies remained low. The PCL/OTC group presented the highest percentage of connective tissue on the 7 th day (p<0.05), and of newly formed bone on the 14 th and 21 st days (p<0.05) after dental extraction, compared to the other groups. The treatment of dry socket with the PCL/OTC fiber allowed almost complete tissue regeneration up to the 21 st day, and the chronology of tissue regeneration with this material was faster than with the plain PCL fiber, and the latter was more rapid than the positive control Alvogyl TM. The PCL/OTC group presented a lower amount (p<0.05) of osteoclasts per area than the other two groups in the three experimental periods. The prolonged release profile of OTC and the relevant biological properties presented by the PCL/OTC nanofibers suggest that th...

show abstract

Drug-induced angioedema: experience of Italian emergency departments

et al. 2013

View full text Add to dashboard Cite

Acute angioedema represents a cause of admission to the emergency department requiring rapid diagnosis and appropriate management to prevent airway obstruction. Several drugs, including angiotensin-converting enzyme inhibitors (ACE-I), nonsteroidal anti-inflammatory drugs (NSAIDs) and oral antidiabetics, have been reported to induce angioedema. The aim of this prospective observational study conducted in a setting of routine emergency care was to evaluate the incidence and extent of drug-induced non-histaminergic angioedema in this specific clinical setting, and to identify the class of drugs possibly associated with angioedema. Patients admitted to seven different emergency departments (EDs) in Rome with the diagnosis of angioedema and urticaria were enrolled during a 6-month period. Of the 120,000 patients admitted at the EDs, 447 (0.37 %) were coded as having angioedema and 655 (0.5 %) as having urticaria. After accurate clinical review, 62 cases were defined as drug-induced, non-histaminergic angioedema. NSAIDs were the most frequent drugs (taken by 22 out of 62 patients) associated with the angioedema attack. Of the remaining patients, 15 received antibiotic treatment and 10 antihypertensive treatment. In addition, we observed in our series some cases of angioedema associated with drugs (such as antiasthmatics, antidiarrheal and antiepileptics) of which there are few descriptions in the literature. The present data, which add much needed information to the existing limited literature on drug-induced angioedema in the clinical emergency department setting, will provide more appropriate diagnosis and management of this potentially life-threatening adverse event.

show abstract

A Case of Anaphylaxis to Oral Minocycline

Cited by 20 publications

References 12 publications

Allergic reaction to the tetracycline component of Ledermix paste: a case report

Allergic reaction to the tetracycline component of Ledermix paste: a case report

Nanofibras poliméricas carregadas com oxitetraciclina para tratamento de alveolite seca: estudo em ratos

Drug-induced angioedema: experience of Italian emergency departments

Contact Info

Product

Resources

About