A case of angiolymphoid hyperplasia with eosinophilia successfully treated with tacrolimus ointment

Abstract

well as salt water soaks considerably decreases the minimal erythema dose. 9,10 So, if enhanced UV gain is the mode of action in BPT, one may question whether broadband UVB following bathing might yield a better synergistic effect than NB-UVB.To date, the BPT studies conducted by Dawe et al. 1 and Léauté-Labrèze et al. 2 have been the most useful clinical approaches in order to estimate whether there is any additional effect of salt water soaks prior to phototherapy. The results obtained from these observations will put the data of numerous previous retrospective and prospective uncontrolled investigations into perspective and may 'downregulate' the enthusiasm of many BPT followers, particularly in Germany. Nevertheless, the conclusion of the previously published controlled trials on BPT suggest a small beneficial effect of using salt water soaks prior to phototherapy. 1,2,5-7 Beyond pure efficacy rates, we have also to take into account the high acceptance of BPT by patients with psoriasis, possibly indicating a holistic approach including time for relaxation and psychological effects that may contribute significantly to the clearance of psoriasis. 1 Disregarding the slight therapeutic benefit from bathing prior to phototherapy, we have to consider the economical and practical drawbacks of BPT. 3,4 Conclusively, in special medical settings (e.g. rehabilitation clinics), particularly where natural resources (e.g. spas) can be used, it is certainly justified to employ BPT for routine use. However, there is no good reason to recommend the general replacement of phototherapy with BPT.

Angiolymphoid Hyperplasia With Eosinophilia

“…29,30 New regimens have been extensively investigated and have shown promising results, including topical imiquimod, tacrolimus, isotretinoin, and interferon a-2a. [31][32][33][34] Concerning the prognosis of ALHE/EH, it tends to persist for years without regressing spontaneously except for occasional cases, which makes surgical or medical intervention necessary in most cases. 3,4,24 CONCLUSION Angiolymphoid hyperplasia with eosinophilia/EH is an uncommon idiopathic lesion characterized by proliferation of histiocytoid endothelial cells with lymphoid and eosinophilic inflammatory infiltration.…”

Unusual presentation of angiolymphoid hyperplasia with eosinophilia treated with intralesional and topic corticosteroid combination therapy

“…The gold standard treatment is the radical surgical excision; but these lesions can also be treated by pulsed-dye la-ser,10 carbon dioxide laser, 11 electro-desiccation, cryotherapy, 12 systemic corticosteroids, intra-lesional injection of corticosteroids or sclerosing agents, intra-muscular injection of corticosteroids, 13 photodynamic therapy,7 interfer-on alpha-2, 13 isotretinoin and tacrolimus. [14][15][16]…”

Angiolymphoid hyperplasia with eosinophilia: An unusual presentation in a child

“…Treatment with interferon-alpha 2B, tacrolimus, and imiquod has been reported to be successful in isolated case reports. [9][10][11] Although surgical excision has a recurrence rate of 33%, it is still considered the treatment of choice. 12 …”