A case of anti-NMDA-receptor encephalitis presenting as febrile catatonia

Шмуклер, А. Б.; Ивашкина, А. А.; Мурашко, А. А.

doi:10.20538/1682-0363-2019-4-266-272

Cited by 6 publications

(3 citation statements)

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“…Together, these studies suggest that psychotic patients with ABs against NMDAR NR1 in serum only and without clinical signs of anti-NMDAR encephalitis could be treated with traditional medications. On the other hand, several attempts to prescribe immunotherapy in AB-positive purely psychotic patients were associated with good outcomes in a number of case reports or case series [97, 99, 100]. Moreover, small studies reported “dramatic improvement” in all but one of the patients following immunotherapy (even in patients who tested positive only for NMDAR NR1/NR2) [101, 102].…”

Section: Discussionmentioning

confidence: 99%

Antibodies against N-Methyl D-Aspartate Receptor in Psychotic Disorders: A Systematic Review

et al. 2021

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Objective: The objective of this study was to provide comprehensive evidence synthesis including all available up-to-date data about the prevalence of N-methyl D-aspartate receptor (NMDAR) antibodies (ABs) in psychotic patients in order to evaluate the clinical relevance of ABs as well as to specify potential explanations of the heterogeneity of the findings and determine areas for further research. Methods: A literature search was conducted using the PubMed/Medline, Web of Knowledge, and Scopus databases. Results: Forty-seven studies and 4 systematic reviews (including 2 meta-analyses) were included in the present review. Studies that used cell-based assays (CBAs) provided heterogeneous results on AB prevalence, obviously depending on the type of detection assay and sample characteristics. Improvement of AB detection methods is necessary to determine the real prevalence of ABs across different groups of patients and healthy people. Live CBAs seem to have better sensitivity but probably poorer specificity than fixed CBAs. Moreover, some links between AB-positive status and acute symptoms are possible. A small amount of data on immunotherapy in AB-positive patients raises the possibility of its effectiveness but obviously require further research. Conclusions: NMDAR ABs are definitely present in a subset of psychotic patients. NMDAR ABs might shape psychosis and underlie some symptoms, and immunotherapy might be regarded as a treatment option for patients failing to respond to other therapies.

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Section: Discussionmentioning

confidence: 99%

Antibodies against N-Methyl D-Aspartate Receptor in Psychotic Disorders: A Systematic Review

et al. 2021

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“…This refers to the study of evoked potentials, 50 , 51 in particular, the study of facial expressions, 52 , 53 , 54 , 55 the study of oculomotor alterations in patients with schizophrenia spectrum disorders 56 and autoimmune disorders in newly emerging psychotic states. 56 , 57 , 58 , 59 In general, the task is to carry out a network analysis of the identified disorders. 60 , 61 , 62 …”

Section: Discussionmentioning

confidence: 99%

“…This refers to the study of evoked potentials, 50,51 in particular, the study of facial expressions, [52][53][54][55] the study of oculomotor alterations in patients with schizophrenia spectrum disorders 56 and autoimmune disorders in newly emerging psychotic states. [56][57][58][59] In general, the task is to carry out a network analysis of the identified disorders. [60][61][62] Thus, the research carried out at the present time preserves the tradition of an integrated clinical and social approach, on the basis of which organizational models of psychiatric services are proposed.…”

Section: Care System For Special Patient Groupsmentioning

confidence: 99%

Comprehensive Clinical and Social Research at the Moscow Research Institute of Psychiatry: Translation into Clinical Practice

Шмуклер¹,

Борисович²,

Movina³

et al. 2021

Consortium Psychiatricum

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The article is devoted to the work of the Moscow Research Institute of Psychiatry to improve psychiatric care for patients with psychotic disorders. An important feature of this work was an integrated approach, in which the clinical picture of the disease was assessed in close connection with the patient's personal and psychological characteristics, social conditions of his life, therapeutic opportunities, rehabilitation potential and organizational structure of care. The article reflects the results of many years of work of the department of outpatient psychiatry and the organization of psychiatric care under the guidance of Professor I.Ya. Gurovich. The results of scientific research carried out by the staff of the institute in a traditional humanistic manner are presented. The translational nature of the research is emphasized by its inextricable link with clinical and social approaches. As a result of many years of work, a concept was developed to provide assistance to various groups of patients, starting with the first manifestations of the disease and ending with cases of long-term chronic disorders with a pronounced level of social maladaptation. As a result, a whole spectrum of new organizational forms of psychiatric care was proposed, such as departments (clinics) of the first psychotic episode, medical rehabilitation departments, assertive community treatment departments, designed for the most difficult patients. These organizational forms were fixed in the regulatory documents of the Ministry of Health and Social Development of the Russian Federation. To date, the above departments have been established in psychiatric institutions in many regions of the Russian Federation. Further development of this area is associated with neurobiological research to identify complex biomarkers of psychotic spectrum disorders. Thus, the research carried out at the present time preserves the tradition of an integrated clinical and social approach to the study of mental disorders. It is shown that an important advantage of this approach is their translational nature.

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Is anti-NMDA receptor encephalitis real? I. Diagnostic challenges

Snedkov,

Volchek,

Lemeshev

2024

Neurology bulletin

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After conducting a thorough analysis of clinical, neurophysiological, neuroimmunological, neurobiological, and neuropathological research findings, the authors of the review question on the validity of the anti-NMDA receptor encephalitis concept. The review highlights the significance of studying sanogenetic mechanisms in medicine and warns against hasty interpretations of neurobiological data without clinical knowledge.

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A case of anti-NMDA-receptor encephalitis presenting as febrile catatonia

Cited by 6 publications

References 5 publications

Antibodies against N-Methyl D-Aspartate Receptor in Psychotic Disorders: A Systematic Review

Antibodies against N-Methyl D-Aspartate Receptor in Psychotic Disorders: A Systematic Review

Comprehensive Clinical and Social Research at the Moscow Research Institute of Psychiatry: Translation into Clinical Practice

Is anti-NMDA receptor encephalitis real? I. Diagnostic challenges

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