A Case of Antiphospholipid Syndrome Following Gastric Signet Ring Cell Adenocarcinoma

Abstract

Rare disease Background:Antiphospholipid syndrome (APS) is a rare autoimmune disease characterized by arterial, venous, and smallvessel thrombosis, pregnancy-related morbidity and the presence of antiphospholipid antibodies such as anticardiolipin antibody, and/or anti-beta2-glycoprotein I. In the recent years, APS was observed in patients with solid tumors and the renal cancer, lung carcinoma and breast tumors were the most common tumors linked with APS. Case Report:A 53-year-old female presented with pain and pitting edema of left lower extremity that had begun 6 months prior to hospitalization. Deep vein thrombosis (DVT) in the popliteal vein diagnosed by Doppler ultrasonography and the patient was treated with heparin followed by warfarin. Following subdural hematoma, anticoagulant therapy was stopped, and the patient underwent craniotomy. One month later, the patient returned with pain and DVT diagnosed in its right leg. Laboratory tests showed high levels of lupus anticoagulant, IgM and IgG anticardiolipin antibodies. Following a high alkaline phosphatase, diffuse bone marrow involvement was found by whole body bone scan. Looking to find primary tumor, a large infilterable lesion in gastric was seen by endoscopic images, and biopsy histopathology showed a signet ring cell adenocarcinoma. The patient refused chemotherapy and died 6 months after diagnosis. Conclusions:APS is associated with gastric signet ring cell adenocarcinoma.

Triple Positive Antiphospholipid Syndrome in a Patient with Rectosigmoid Colon Cancer- a Rare Occurrence

“…Case reports have also confirmed that the most common solid malignancies associated with APS were kidney, breast, ovarian, and lung cancers [3]. Some reports have also demonstrated an association between gastrointestinal cancers, such as gastric signet ring cell adenocarcinoma and aPL [5]. A previous study showed that moderate-to-high levels of antiphospholipid antibodies were present in a sample of 53 patients with positive CEA and CA19-9 tumor markers, suggesting a possible association with gastrointestinal tumors [6].…”

Using Compression Therapy to Treat Bilateral Lower Limb Edema in Patients with Lung Cancer: A Case Series

“…Rather than relying on the administration of diuretics, providers should aim to take a nonpharmacologic approach when appropriate. In patients with urologic, gynecologic, and gastrointestinal cancers, intraperitoneal lymph nodes, spinal cord metastasis, and iliac and leg vein thrombosis can cause BLE 22–25 . In recent years, clinicians have used ICIs to treat patients with these cancers as well as patients with lung cancer, and the possibility of long-term survival has been documented 8 .…”

“…In patients with urologic, gynecologic, and gastrointestinal cancers, intraperitoneal lymph nodes, spinal cord metastasis, and iliac and leg vein thrombosis can cause BLE. [22][23][24][25] In recent years, clinicians have used ICIs to treat patients with these cancers as well as patients with lung cancer, and the possibility of longterm survival has been documented. 8 With ICI therapy, IRAEs can occur in organs throughout the body and require appropriate treatment.…”