A case of basaloid squamous cell carcinoma of the maxilla treated successfully by superselective intra-arterial chemotherapy with radiotherapy

Basaloid squamous cell carcinoma of the floor of the mouth: A case report with review of the literature

“…47 Although it has been reported that the positivity rate of HPV DNA is significantly higher in HNBSCC than in SCC, 42 no reports to date have investigated the HPV in OBSCC. In this study, we found that only one case performed immunohistological staining for p16 33 ; however, only the present case performed HPV DNA detection. Therefore, the involvement of HPV in OBSCC is insignificant in this study.…”

“…The present case suggested a possibility of false positive for p16 by PCR analysis, using the primer for HPV16, HPV18, and GP5+/ GP6+, a general primer for HPV; the presence of HPV cannot be completely ruled out because GP5+/GP6+ detects HPV6, 11,16,18,31,33,34,35,39,40,42,43,44,45, 51, 52, 54, 56, 58. 43,44 It has been reported that the false-positive rate of p16 in oropharyngeal SCC is 10%-30%, 45 whereas it is as high as 70% in OSCC.…”

“…The frequency of occurrence is as low as 2%‐5% of all head and neck cancers 6,9 . In this study, we reviewed 27 cases of OBSCC reported in Japan between January 2001 and January 2020 10‐34 (Table 1). According to the present study, the incidence was the highest in those in their 60s, with men accounting for most patients.…”