A Case of Behçet’s Disease and Systemic Sclerosis Developing After an Earthquake Disaster

Watanabe, Hiroshi; Yashiro, Makiko; Asano, Tomohiko; Sato, Shuzo; Takahashi, Atsushi; Katakura, Kyoko; Kobayashi, Hiroko; Ohira, Hiromasa

doi:10.5387/fms.2014-27

Cited by 4 publications

References 15 publications

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Using Hierarchical Similarity To Examine The Genetics of Behçet’s Disease

2021

Preprint

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Behçet's disease (BD) is a multisystem inflammatory disease that effects patients along the historic silk road. Thus far, the patheogensis of the disease has proved elusive due to the complex genetic interactions and unknown environmental or viral triggering factors of the disease. In this paper, we seek to clarify the gentic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. To do this, we employ a computational functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the patheogenesis of Behçet's Disease.

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Using Hierarchical Similarity To Examine The Genetics of Behçet’s Disease

2021

Preprint

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Using hierarchical similarity to examine the genetics of Behçet’s disease

Shenoi

Baker

2021

BMC Res Notes

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Objective Behçet’s disease (BD) is a multisystem inflammatory disease that affects patients along the historic silk road. Thus far, the pathogenesis of the disease has proved elusive due to the complex genetic interactions of the disease. In this paper, we seek to clarify the genetic factors of the disease while also uncovering other diseases of interest that present with a similar genotype as BD. Results To do this, we employ a convergent functional genomics approach by leveraging the hierarchical similarity tool available in Geneweaver. Through our analysis, we were able to ascertain 7 BD consensus genes and 16 autoimmune diseases with genetic overlap with BD. The results of our study will inform further research into the pathogenesis of Behçet’s disease.

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Peptic Ulcers in Fukushima Prefecture Related to the Great East Japan Earthquake, Tsunami and Nuclear Accident

et al. 2018

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Objective Due to the Great East Japan Earthquake, which occurred in March 2011, many residents of Fukushima Prefecture were affected by a radiation accident in addition to suffering loss or damage from the earthquake and the subsequent tsunami. The aim of this study was to evaluate the actual condition of patients with peptic ulcers related to the disaster. Methods Patients with peptic ulcers at six hospitals in three different regions of Fukushima Prefecture during the two months following the disaster and the corresponding period of the year before and the year after the disaster were enrolled in this study. Changes by period and region in the number of esophagogastroduodenoscopy (EGD) examinations and the number of peptic ulcer patients were evaluated as the primary endpoints. Changes in the frequencies of hemorrhagic ulcers were evaluated by period and by region as secondary endpoints. Results The numbers of EGDs and peptic ulcer cases compared to the previous year decreased in 2011 and then increased in 2012. However, the ratio of hemorrhagic ulcers to peptic ulcers was higher in 2011 (51.9%) than in 2010 (38.1%) and 2012 (31.1%), and the 2011 hemorrhagic ulcer ratio was the highest at 63.6% in the coastal area. Regarding bleeding cases during 2011, the rate at 1 month after the disaster (64.1%) was higher than the rate at 2 months after the disaster (40.5%) (p=0.033). Conclusion The number of patients with peptic ulcers did not increase immediately following the disaster in Fukushima Prefecture. However, the rate of bleeding patients increased soon after the disaster, especially in the coastal area.

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A Case of Behçet’s Disease and Systemic Sclerosis Developing After an Earthquake Disaster

Cited by 4 publications

References 15 publications

Using Hierarchical Similarity To Examine The Genetics of Behçet’s Disease

Using Hierarchical Similarity To Examine The Genetics of Behçet’s Disease

Using hierarchical similarity to examine the genetics of Behçet’s disease

Peptic Ulcers in Fukushima Prefecture Related to the Great East Japan Earthquake, Tsunami and Nuclear Accident

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