A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum

Sravanti, K; Pravalika, B; Pavani, M; Ashwini, M; Lakshmi, V

doi:10.1016/j.mmcr.2022.05.001

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…26 Among antifungals, the broad-spectrum voriconazole showed relatively lower MIC values and superior activity in the S. apiospermum infection therapy, 27,28 which has been recommended as the firstline therapy in most cases. [29][30][31] In addition, susceptibility testing was performed due to the inherent resistance of S. apiospermum and identified that this fungus was susceptible to itraconazole, posaconazole, and voriconazole, which is consistent with previous reports. 31 Accordingly, voriconazole was selected as the primary option for our case.…”

Section: Discussionsupporting

confidence: 87%

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

Pan,

Huang,

Xie

et al. 2023

IDR

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Scedosporium apiospermum ( S. apiospermum ) is typically reported to be involved in superficial and subcutaneous fungal infections but overlooked in invasive infections, which is associated with a high mortality rate. It poses a diagnostic challenge due to its confusable characteristics to other hyaline hyphomycetes. Here, we reported a psoriasis patient with an invasive S. apiospermum infection. The patient presents an abscess at the intermuscular space of the left hip and an increased C-reactive protein level. Pus culture showed white-greyish, cottonlike colonies with aerial mycelium and terminal oval conidia, suggesting S. apiospermum . This rare fungus was rapidly confirmed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and RNA sequencing. The patient was successfully treated with voriconazole with no recurrence of the abscesses despite delayed treatment. This is the first such case infection report from China that described an unusual case of intermuscular space abscesses due to S. apiospermum . This report highlights the possibility of fungal infections in deeper tissue, as well as the necessity of thorough evaluation and microbiological diagnosis for invasive infections, particularly in immunocompromised patients.

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Section: Discussionsupporting

confidence: 87%

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

Pan,

Huang,

Xie

et al. 2023

IDR

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Epidemiology of rare bacterial, parasitic, and fungal pathogens in India

Sharma,

Krishnaswamy,

Chaturvedi

et al. 2024

IJID Regions

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Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

Neoh,

Chen,

Lanternier

et al. 2024

Clin Microbiol Rev

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SUMMARY Although Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal susceptibility, and treatment. An expansion of hosts at risk for these difficult-to-treat infections has emerged over the last two decades given the increased use of, and broader population treated with, immunomodulatory and targeted molecular agents as well as wider adoption of antifungal prophylaxis. Clinical presentations differ not only between genera but also across the different Scedosporium species. L. prolificans is intrinsically resistant to most currently available antifungal agents, and the prognosis of immunocompromised patients with lomentosporiosis is poor. Development of, and improved access to, diagnostic modalities for early detection of these rare mold infections is paramount for timely targeted antifungal therapy and surgery if indicated. New antifungal agents (e.g., olorofim, fosmanogepix) with novel mechanisms of action and less cross-resistance to existing classes, availability of formulations for oral administration, and fewer drug-drug interactions are now in late-stage clinical trials, and soon, could extend options to treat scedosporiosis/lomentosporiosis. Much work remains to increase our understanding of these infections, especially in the pediatric setting. Knowledge gaps for future research are highlighted in the review.

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A case of bilateral injection abscesses caused by Graphium type of Scedosporium apiospermum

Cited by 4 publications

References 18 publications

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

A Case of Invasive Fungal Infection Due to Scedosporium apiospermum in a Patient with Psoriasis

Epidemiology of rare bacterial, parasitic, and fungal pathogens in India

Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections

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