A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm with Unusual Presentation

Dhariwal, Sneha; Gupta, Monica

doi:10.4274/tjh.galenos.2018.2018.0181

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…The skin lesions are usually manifested as bruise-like lesions, plaques or nodules on the head, trunk, and extremities (6). A small percentage of patients will present with isolated skin disease, while the majority of patients has extracutaneous manifestations, including lymphadenopathy, fever, fatigue, or testicular swelling, but rarely have massive splenomegaly or hypersplenism (15)(16)(17)(18)(19). The diagnosis of BPDCN is mainly based on histology, immunohistochemistry, and flow cytometry (3,4,20).…”

Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

Chen,

Zhang,

et al. 2023

Front. Med.

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BackgroundBlastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare hematopoietic malignancy, which originating from precursors of plasmacytoid dendritic cells. Allogeneic hematopoietic stem cell transplantation (HSCT) is normally considered in the treatment of BPDCN patients to acquire sustained remission. Post-transplant lymphoproliferative disorder (PTLD) is a group of conditions involving abnormal lymphoid cells proliferation in the context of extrinsic immunosuppression after solid organ transplantation (SOT) or HSCT. Herein, we report a patient with BPDCN, who suffered from PTLD after allogeneic HSCT.Case presentationA 66-year-old man was diagnosed with BPDCN, confirmed by pathologic examination after splenectomy. The post-surgery 18F-fluoro-2-deoxy-D-glucose-positron emission tomography/computed tomography (18F-FDG PET/CT) showed multifocal 18F-FDG avidity in the left cheek, lymph nodes and bone marrow. The patient started chemotherapy, followed by allogeneic HSCT and immunosuppressive therapy. Four months after the HSCT, the patient developed intermittent fever and recurrent lymphadenopathy, accompanied with progressively elevated Epstein–Barr virus (EBV)-DNA both in serum and lymphocytes. 18F-FDG PET/CT was performed again and found multiple new enlarged 18F-FDG-avid lymph nodes, while the previous hypermetabolic lesions all disappeared. The pathology of mesenteric lymph node indicated a monomorphic PTLD (diffuse large B-cell lymphoma). Then the immunosuppressive medications were stopped and two cycles of Rituximab were given, and the follow-up CT scan indicated a complete response.ConclusionWhen patients with BPDCN recurred new enlarged lymph nodes after allogeneic HSCT and immunosuppressive therapy, PTLD should be taken into consideration. 18F-FDG PET/CT may provide additional evidence for supporting or refuting the suspicion of PTLD, and suggest lesions accessible for biopsy.

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Section: Discussionmentioning

confidence: 99%

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

Chen,

Zhang,

et al. 2023

Front. Med.

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“…However, initial manifestations of BPDCN without cutaneous involvement are extremely rare. Dhariwal et al recently described a case of a 13-year-old male who initially presented with BPDCN manifesting as a testicular mass without any cutaneous manifestation followed by leukemia-like symptoms with bone marrow involvement [6]. Lee et al described two cases of adolescent females who initially presented with BPDCN manifesting as nasal cavity masses with leukemic involvement without any cutaneous manifestation [7].…”

Section: Discussionmentioning

confidence: 99%

An Unusual Manifestation of Blastic Plasmacytoid Dendritic Cell Neoplasm as a Testicular Tumor

Pak

Tretiakova

2019

Case Reports in Pathology

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive hematologic malignancy arising from precursors of plasmacytoid dendritic cells that represent less than 1% of hematological malignancies. BPDCN initially presents with cutaneous involvement and a characteristic immunophenotype of CD4, CD56, and CD123 co-expression. Upon disease progression, BPDCN shows a strong predilection for bone marrow, peripheral blood, and lymph nodes, whereas manifestations in visceral organs are rare. Significant heterogeneity in clinical presentation and immunophenotypic profile makes BPDCN challenging to diagnose without an integrated approach based on patient history, clinical features, tumor pathology, and comprehensive immunohistochemical studies. Herein we report the first case of relapsed BPDCN manifesting as a unilateral testicular tumor.

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Blastic Plasmacytoid Dendritic Cell Neoplasm

Deconinck

2020

Hematology/Oncology Clinics of North America

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A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm with Unusual Presentation

Cited by 6 publications

References 7 publications

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

18F-FDG PET/CT findings in a patient with blastic plasmacytoid dendritic cell neoplasm and post-transplant lymphoproliferative disorder after hematopoietic stem cell transplantation: a case report

An Unusual Manifestation of Blastic Plasmacytoid Dendritic Cell Neoplasm as a Testicular Tumor

Blastic Plasmacytoid Dendritic Cell Neoplasm

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