A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis

Abstract

A case of breast cancer that metastasized to the cervix 10 years and 8 months after mastectomy is reported. The patient had undergone pancreaticoduodenectomy due to solitary metastasis to the head of the pancreas 4 years previously. The cervical metastasis was associated with abnormal genital bleeding. After pancreaticoduodenectomy the serum levels of CEA, CA15-3 and NCC-ST-439, which are markers of breast cancer, were within normal limits, but the serum level of CA15-3 had increased month by month. The patient had abnormal genital bleeding and presented to the department of gynecology at our hospital. The tumor was in the cervix, bled easily and 2.5x2.0 cm in size on ultrasonography. It was thought to be carcinoma of the cervix, but biopsy revealed the tumor to be an adenocarcinoma pathologically and CA15-3 was immunohistochemically demonstrated in the resected specimen, similar to lobular carcinoma of the breast. Abdominal CT scan revealed involvement of the ovaries and uterus, prompting hysterectomy with bilateral oophorectomy. After discharge, she received chemoendocrine therapy. However, she subsequently died due to peritoneal carcinomatosis.

Adenocarcinoma metastatic to the uterine cervix: A case series

“…Finally, we excluded any references that were not available in complete text form or lacked the data we required for this analysis (Table 2). For the purposes of our review, we included 13/16 (81.2%) publications associated with gastric cancer, 14–28 30/45 (66.6%) with breast cancer, 14,18,21,29–55 9/13 (69.2%) with ovarian cancer, 15,18,21,29,56–60 and 10/13 reports (76.9%) related to colorectal cancer 15,18,19,21,61–66 . The total number of patients covered in these reports was 45 for gastric cancer, 36 for breast cancer, 36 for ovarian cancer and 19 for colorectal cancer.…”

Pancreatic metastasis from invasive pleomorphic lobular carcinoma of the breast: a rare case report

“…It has been reported that ILC metastasizes to organs such as the pancreas, uterus, gastrointestinal tract, urinary tract, reproductive organs and the retroperitoneum after a long disease-free interval [17]. In contrast, our patient with PLC had a fairly rapid recurrence, highlighting the potential significant difference in the underlying biology of these two tumors.…”

Metastatic Breast Cancer of the Cervix Presenting in Labor

“…It is thought that oxygen tension in the ovaries and other metabolic features make it a preferred site for metastatic disease. It is reported that the cervix is a less usual site because of the smallness of the organ, not abundant blood supply and having just one afferent drainage system 7,8 .…”